DegronMD

Uniprot ID: Q9UKT9

Source protein: Zinc finger protein Aiolos

Source gene: IKZF3

Class: DEG_Kelch_Keap1_1

Location: 39:44

E3 ligase: KEAP1

DEGRON score: 0.9613

ASA_SCORE: 71.9

COIL: 0.8095

CONS_SCORE: 0.4691

DSS_SCORE: 0.747

HELIX: 0.0308

FCONS_SCORE: 0.9983

RIG_SCORE: 0.601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G54A	TCGA-19-1790	GBM	TCGA	NVDSGE	DEG_Kelch_Keap1_1	0.0556
p.G54A	DO12328	GBM	ICGC	NVDSGE	DEG_Kelch_Keap1_1	0.0556
p.H35D	TCGA-73-4658	LUAD	TCGA	NVDSGE	DEG_Kelch_Keap1_1	0.2222
p.H35D	DO23663	LUAD	ICGC	NVDSGE	DEG_Kelch_Keap1_1	0.2222
p.E49K	TCGA-AA-3851	COAD	TCGA	NVDSGE	DEG_Kelch_Keap1_1	0.1944
p.E49K	DO9972	COAD	ICGC	NVDSGE	DEG_Kelch_Keap1_1	0.1944
p.A47V	TCGA-CS-5390	LGG	TCGA	NVDSGE	DEG_Kelch_Keap1_1	0.25
p.A47V	DO22688	LGG	ICGC	NVDSGE	DEG_Kelch_Keap1_1	0.25
p.A47D	DO229025	LICA	ICGC	NVDSGE	DEG_Kelch_Keap1_1	0.25
p.D50H	SIDM00528	Breast Carcinoma	GDSC	NVDSGE	DEG_Kelch_Keap1_1	0.1667
p.D50H	MDA-MB-361	breast	COSMIC	NVDSGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKT9	Zinc finger protein Aiolos	DEG_Kelch_Keap1_1	39:44	NVDSGE	KEAP1	0.9613	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons