DegronMD - Q9UKW6(ELF5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V15A	TCGA-B5-A3FA	UCEC	TCGA	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6936
p.V15A	DO52402	UCEC	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6936
p.H8N	TCGA-D3-A2JL	SKCM	TCGA	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6312
p.H8N	DO47278	SKCM	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6312
p.S3F	TCGA-D3-A51G	SKCM	TCGA	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1944
p.S3F	DO47700	SKCM	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1944
p.P22T	DO229041	LICA	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1667
p.T16K	DO229009	LICA	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6195
p.S7F	DO222731	MELA	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.3056
p.S7F	DO229465	SKCA	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.3056
p.S25F	DO229462	SKCA	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.0833
p.S14L	SIDM00433	T-Lymphoblastic Leukemia	GDSC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6556
p.S14L	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.6556
p.S4L	ACH-000795	Leukemia	CCLE	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.2222
p.S4L	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.2222
p.D18N	U251	central nervous system	COSMIC	HRVMLDSVT	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.2778

Kaplan plot for ELF5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ELF5

UniProt ID: Q9UKW6

Entrez ID: 2001

Protein name: ETS-related transcription factor Elf-5 (E74-like factor 5) (Epithelium-restricted ESE-1-related Ets factor) (Epithelium-specific Ets transcription factor 2) (ESE-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ELF5 in