DegronMD

Uniprot ID: Q9UKW6

Source protein: ETS-related transcription factor Elf-5

Source gene: ELF5

Class: DEG_APCC_DBOX_1

Location: 8:16

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8487

ASA_SCORE: 79.2333

COIL: 0.6976

CONS_SCORE: 0.5743

DSS_SCORE: 0.2737

HELIX: 0.1686

FCONS_SCORE: 1.1185

RIG_SCORE: 0.726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V15A	TCGA-B5-A3FA	UCEC	TCGA	HRVMLDSVT	DEG_APCC_DBOX_1	0.6936
p.V15A	DO52402	UCEC	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	0.6936
p.H8N	TCGA-D3-A2JL	SKCM	TCGA	HRVMLDSVT	DEG_APCC_DBOX_1	0.6312
p.H8N	DO47278	SKCM	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	0.6312
p.S3F	TCGA-D3-A51G	SKCM	TCGA	HRVMLDSVT	DEG_APCC_DBOX_1	0.1944
p.S3F	DO47700	SKCM	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	0.1944
p.P22T	DO229041	LICA	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	0.1667
p.T16K	DO229009	LICA	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	0.6195
p.S7F	DO222731	MELA	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	0.3056
p.S7F	DO229465	SKCA	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	0.3056
p.S25F	DO229462	SKCA	ICGC	HRVMLDSVT	DEG_APCC_DBOX_1	0.0833
p.S14L	SIDM00433	T-Lymphoblastic Leukemia	GDSC	HRVMLDSVT	DEG_APCC_DBOX_1	0.6556
p.S14L	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	HRVMLDSVT	DEG_APCC_DBOX_1	0.6556
p.S4L	ACH-000795	Leukemia	CCLE	HRVMLDSVT	DEG_APCC_DBOX_1	0.2222
p.S4L	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	HRVMLDSVT	DEG_APCC_DBOX_1	0.2222
p.D18N	U251	central_nervous_system	COSMIC	HRVMLDSVT	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKW6	ETS-related transcription factor Elf-5	DEG_APCC_DBOX_1	8:16	HRVMLDSVT	APC,CDC20,FZR1	0.8487	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons