DegronMD - Q9UKX5(ITGA11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R104L	TCGA-05-4390	LUAD	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1389
p.R104L	DO23562	LUAD	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1389
p.G81R	TCGA-BR-4253	STAD	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1111
p.G81R	DO38455	STAD	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1111
p.G81R	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1111
p.G81R	ACH-000893	Lung Cancer	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1111
p.G81R	NCI-H1651	lung	COSMIC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1111
p.E98K	TCGA-CC-A7IF	LIHC	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.E98K	DO52177	LIHC	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.E98K	SIDM00125	Kidney Carcinoma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.E98K	SIDM01138	Pancreatic Carcinoma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.E98K	ACH-000139	Pancreatic Cancer	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.E98K	ACH-000649	Kidney Cancer	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.E98K	PANC-03-27	pancreas	COSMIC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.E98K	786-0	kidney	COSMIC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.3056
p.G81W	TCGA-EE-A20F	SKCM	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1111
p.G81W	DO37961	SKCM	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1111
p.R99L	TCGA-ER-A2NH	SKCM	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.2778
p.R99L	DO47683	SKCM	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.2778
p.M103T	TCGA-UY-A8OB	BLCA	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1667
p.M103T	DO219037	BLCA	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1667
p.G89E	TCGA-YG-AA3O	SKCM	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation altering degron motif	0.6087
p.G89E	DO51299	SKCM	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation altering degron motif	0.6087
p.R104H	DO232224	PBCA	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1389
p.N82K	SIDM00131	Glioma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1389
p.N82K	ACH-000329	Brain Cancer	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1389
p.N82K	CCF-STTG1	central nervous system	COSMIC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1389
p.V96M	SIDM01198	Burkitt's Lymphoma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation altering degron motif	0.6097
p.N102S	SIDM00118	Colorectal Carcinoma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1944
p.N102S	ACH-001081	Colon/Colorectal Cancer	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1944
p.N102S	HCC2998	large intestine	COSMIC	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1944
p.M103L	ACH-001751	Sarcoma	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	89:97	Mutation rewiring degron network	0.1667

Kaplan plot for ITGA11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGA11

UniProt ID: Q9UKX5

Entrez ID: 22801

Protein name: Integrin alpha-11

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITGA11 in