DegronMD

Uniprot ID: Q9UKX5

Source protein: Integrin alpha-11

Source gene: ITGA11

Class: DEG_APCC_DBOX_1

Location: 89:97

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6197

ASA_SCORE: 72.1444

COIL: 0.7656

CONS_SCORE: 0.4471

DSS_SCORE: 0.3346

HELIX: 0.0849

FCONS_SCORE: 0.8965

RIG_SCORE: 0.8168

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R104L	TCGA-05-4390	LUAD	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	0.1389
p.R104L	DO23562	LUAD	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1389
p.G81R	TCGA-BR-4253	STAD	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	0.1111
p.G81R	DO38455	STAD	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1111
p.G81R	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1111
p.G81R	ACH-000893	Lung Cancer	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	0.1111
p.G81R	NCI-H1651	lung	COSMIC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1111
p.E98K	TCGA-CC-A7IF	LIHC	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	0.3056
p.E98K	DO52177	LIHC	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	0.3056
p.E98K	SIDM00125	Kidney Carcinoma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	0.3056
p.E98K	SIDM01138	Pancreatic Carcinoma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	0.3056
p.E98K	ACH-000139	Pancreatic Cancer	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	0.3056
p.E98K	ACH-000649	Kidney Cancer	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	0.3056
p.E98K	PANC-03-27	pancreas	COSMIC	GRVTLSNVS	DEG_APCC_DBOX_1	0.3056
p.E98K	786-0	kidney	COSMIC	GRVTLSNVS	DEG_APCC_DBOX_1	0.3056
p.G81W	TCGA-EE-A20F	SKCM	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	0.1111
p.G81W	DO37961	SKCM	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1111
p.R99L	TCGA-ER-A2NH	SKCM	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	0.2778
p.R99L	DO47683	SKCM	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	0.2778
p.M103T	TCGA-UY-A8OB	BLCA	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	0.1667
p.M103T	DO219037	BLCA	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1667
p.G89E	TCGA-YG-AA3O	SKCM	TCGA	GRVTLSNVS	DEG_APCC_DBOX_1	0.6087
p.G89E	DO51299	SKCM	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	0.6087
p.R104H	DO232224	PBCA	ICGC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1389
p.N82K	SIDM00131	Glioma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1389
p.N82K	ACH-000329	Brain Cancer	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	0.1389
p.N82K	CCF-STTG1	central_nervous_system	COSMIC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1389
p.V96M	SIDM01198	Burkitt's Lymphoma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	0.6097
p.N102S	SIDM00118	Colorectal Carcinoma	GDSC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1944
p.N102S	ACH-001081	Colon/Colorectal Cancer	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	0.1944
p.N102S	HCC2998	large_intestine	COSMIC	GRVTLSNVS	DEG_APCC_DBOX_1	0.1944
p.M103L	ACH-001751	Sarcoma	CCLE	GRVTLSNVS	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRVTLSNVS

Degron related mutations and impact score

Drug responses associated with ITGA11 mutations

All proteins holding degron of GRVTLSNVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKX5	Integrin alpha-11	DEG_APCC_DBOX_1	89:97	GRVTLSNVS	APC,CDC20,FZR1	0.6197	More...