DegronMD - Q9UL12(SARDH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E462D	TCGA-17-Z031	LUAD	TCGA	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.0833
p.L478P	TCGA-17-Z049	LUAD	TCGA	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.2778
p.E462Q	TCGA-66-2766	LUSC	TCGA	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.0833
p.E462Q	DO27747	LUSC	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.0833
p.R481H	TCGA-AA-3664	COAD	TCGA	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.1944
p.D475V	TCGA-BG-A222	UCEC	TCGA	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation altering degron motif	0.6674
p.R481C	TCGA-BR-8487	STAD	TCGA	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.1944
p.R481C	DO47867	STAD	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.1944
p.S463F	TCGA-EE-A2MR	SKCM	TCGA	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.1111
p.S463F	DO37819	SKCM	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.1111
p.A465V	TCGA-F7-A624	HNSC	TCGA	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.1667
p.M480V	DO229010	COCA	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.2222
p.M480V	DO229013	COCA	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.2222
p.M480V	DO229016	COCA	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.2222
p.M480V	DO229003	COCA	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.2222
p.M480V	DO229047	LICA	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.2222
p.M480V	DO229054	LICA	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.2222
p.M480V	DO231051	LUSC	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.2222
p.A485T	DO222702	MELA	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.0833
p.A485T	DO40978	UCEC	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.0833
p.A485T	DO43803	UCEC	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.0833
p.S461I	DO43755	UCEC	ICGC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.0556
p.A479P	SIDM01233	Colorectal Carcinoma	GDSC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.25
p.A479P	ACH-000009	Colon/Colorectal Cancer	CCLE	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.25
p.A479P	C2BBe1	large intestine	COSMIC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.25
p.P473R	SIDM01093	Cervical Carcinoma	GDSC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation altering degron motif	0.7512
p.P473R	ACH-000556	Cervical Cancer	CCLE	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation altering degron motif	0.7512
p.P473R	SiHa	cervix	COSMIC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation altering degron motif	0.7512
p.N482I	SIDM01664	Prostate Carcinoma	GDSC	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.1667
p.N482I	ACH-000952	Prostate Cancer	CCLE	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.1667
p.V470I	ACH-001607	Gallbladder Cancer	CCLE	VFPHDE	LIG_APCC_ABBA_1	471:476	Mutation rewiring degron network	0.3056

Kaplan plot for SARDH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SARDH

UniProt ID: Q9UL12

Entrez ID: 1757

Protein name: Sarcosine dehydrogenase, mitochondrial (SarDH) (EC 1.5.8.3) (BPR-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SARDH in