DegronMD

Uniprot ID: Q9UL12

Source protein: Sarcosine dehydrogenase, mitochondrial

Source gene: SARDH

Class: LIG_APCC_ABBA_1

Location: 471:476

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9767

ASA_SCORE: 55.0167

COIL: 0.84

CONS_SCORE: 0.3845

DSS_SCORE: 0.3804

HELIX: 0.0957

FCONS_SCORE: 0.9355

RIG_SCORE: 0.7598

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E462D	TCGA-17-Z031	LUAD	TCGA	VFPHDE	LIG_APCC_ABBA_1	0.0833
p.L478P	TCGA-17-Z049	LUAD	TCGA	VFPHDE	LIG_APCC_ABBA_1	0.2778
p.E462Q	TCGA-66-2766	LUSC	TCGA	VFPHDE	LIG_APCC_ABBA_1	0.0833
p.E462Q	DO27747	LUSC	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.0833
p.R481H	TCGA-AA-3664	COAD	TCGA	VFPHDE	LIG_APCC_ABBA_1	0.1944
p.D475V	TCGA-BG-A222	UCEC	TCGA	VFPHDE	LIG_APCC_ABBA_1	0.6674
p.R481C	TCGA-BR-8487	STAD	TCGA	VFPHDE	LIG_APCC_ABBA_1	0.1944
p.R481C	DO47867	STAD	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.1944
p.S463F	TCGA-EE-A2MR	SKCM	TCGA	VFPHDE	LIG_APCC_ABBA_1	0.1111
p.S463F	DO37819	SKCM	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.1111
p.A465V	TCGA-F7-A624	HNSC	TCGA	VFPHDE	LIG_APCC_ABBA_1	0.1667
p.M480V	DO229010	COCA	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.2222
p.M480V	DO229013	COCA	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.2222
p.M480V	DO229016	COCA	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.2222
p.M480V	DO229003	COCA	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.2222
p.M480V	DO229047	LICA	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.2222
p.M480V	DO229054	LICA	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.2222
p.M480V	DO231051	LUSC	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.2222
p.A485T	DO222702	MELA	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.0833
p.A485T	DO40978	UCEC	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.0833
p.A485T	DO43803	UCEC	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.0833
p.S461I	DO43755	UCEC	ICGC	VFPHDE	LIG_APCC_ABBA_1	0.0556
p.A479P	SIDM01233	Colorectal Carcinoma	GDSC	VFPHDE	LIG_APCC_ABBA_1	0.25
p.A479P	ACH-000009	Colon/Colorectal Cancer	CCLE	VFPHDE	LIG_APCC_ABBA_1	0.25
p.A479P	C2BBe1	large_intestine	COSMIC	VFPHDE	LIG_APCC_ABBA_1	0.25
p.P473R	SIDM01093	Cervical Carcinoma	GDSC	VFPHDE	LIG_APCC_ABBA_1	0.7512
p.P473R	ACH-000556	Cervical Cancer	CCLE	VFPHDE	LIG_APCC_ABBA_1	0.7512
p.P473R	SiHa	cervix	COSMIC	VFPHDE	LIG_APCC_ABBA_1	0.7512
p.N482I	SIDM01664	Prostate Carcinoma	GDSC	VFPHDE	LIG_APCC_ABBA_1	0.1667
p.N482I	ACH-000952	Prostate Cancer	CCLE	VFPHDE	LIG_APCC_ABBA_1	0.1667
p.V470I	ACH-001607	Gallbladder Cancer	CCLE	VFPHDE	LIG_APCC_ABBA_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VFPHDE

Degron related mutations and impact score

Drug responses associated with SARDH mutations

All proteins holding degron of VFPHDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UL12	Sarcosine dehydrogenase, mitochondrial	LIG_APCC_ABBA_1	471:476	VFPHDE	APC,CDC20,FZR1	0.9767	More...