DegronMD - Q9UL41(PNMA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G349W	TCGA-37-4130	LUSC	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.6714
p.G349W	DO26490	LUSC	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.6714
p.L350V	TCGA-77-8133	LUSC	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.5654
p.L350V	DO27039	LUSC	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.5654
p.E351K	TCGA-AZ-6603	COAD	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.591
p.E351K	DO10188	COAD	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.591
p.E351D	TCGA-D7-A4YU	STAD	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.5647
p.E351D	DO47761	STAD	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.5647
p.R359M	TCGA-DF-A2KU	UCEC	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1111
p.R359M	DO223286	UCEC	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1111
p.A338V	TCGA-EY-A1GU	UCEC	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1944
p.A338V	DO41518	UCEC	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1944
p.A353V	TCGA-JW-A69B	CESC	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.2778
p.A353V	DO49977	CESC	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.2778
p.P342L	SIDM00909	Melanoma	GDSC	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.3056
p.P342L	ACH-000644	Skin Cancer	CCLE	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.3056
p.P342L	COLO-829	skin	COSMIC	DRESLEGLE	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.3056

Kaplan plot for PNMA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PNMA3

UniProt ID: Q9UL41

Entrez ID: 29944

Protein name: Paraneoplastic antigen Ma3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PNMA3 in