DegronMD

Uniprot ID: Q9UL41

Source protein: Paraneoplastic antigen Ma3

Source gene: PNMA3

Class: DEG_APCC_DBOX_1

Location: 343:351

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9087

ASA_SCORE: 109.8333

COIL: 0.7109

CONS_SCORE: 0.751

DSS_SCORE: 0.5214

HELIX: 0.2198

FCONS_SCORE: 0.9917

RIG_SCORE: 0.7245

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G349W	TCGA-37-4130	LUSC	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	0.6714
p.G349W	DO26490	LUSC	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	0.6714
p.L350V	TCGA-77-8133	LUSC	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	0.5654
p.L350V	DO27039	LUSC	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	0.5654
p.E351K	TCGA-AZ-6603	COAD	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	0.591
p.E351K	DO10188	COAD	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	0.591
p.E351D	TCGA-D7-A4YU	STAD	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	0.5647
p.E351D	DO47761	STAD	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	0.5647
p.R359M	TCGA-DF-A2KU	UCEC	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	0.1111
p.R359M	DO223286	UCEC	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	0.1111
p.A338V	TCGA-EY-A1GU	UCEC	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	0.1944
p.A338V	DO41518	UCEC	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	0.1944
p.A353V	TCGA-JW-A69B	CESC	TCGA	DRESLEGLE	DEG_APCC_DBOX_1	0.2778
p.A353V	DO49977	CESC	ICGC	DRESLEGLE	DEG_APCC_DBOX_1	0.2778
p.P342L	SIDM00909	Melanoma	GDSC	DRESLEGLE	DEG_APCC_DBOX_1	0.3056
p.P342L	ACH-000644	Skin Cancer	CCLE	DRESLEGLE	DEG_APCC_DBOX_1	0.3056
p.P342L	COLO-829	skin	COSMIC	DRESLEGLE	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UL41	Paraneoplastic antigen Ma3	DEG_APCC_DBOX_1	343:351	DRESLEGLE	APC,CDC20,FZR1	0.9087	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons