DegronMD - Q9UL63(MKLN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A302V	TCGA-50-5944	LUAD	TCGA	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.25
p.S314C	TCGA-55-8205	LUAD	TCGA	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1944
p.E318D	TCGA-78-7158	LUAD	TCGA	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.0833
p.V305A	TCGA-A5-A1OF	UCEC	TCGA	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation altering degron motif	0.5825
p.D316E	TCGA-CA-6717	COAD	TCGA	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1389
p.M308T	DO7930	COAD	ICGC	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation altering degron motif	0.7423
p.G313D	DO14160	HNSC	ICGC	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.2222
p.C319F	DO26015	LUAD	ICGC	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation substituting flanking lysine	0.1667
p.C301Y	DO42023	UCEC	ICGC	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.2222
p.S304L	C-4-I	cervix	COSMIC	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.3056
p.M300I	HCC1599	breast	COSMIC	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1944
p.E305A	HCC2998	large intestine	COSMIC	VKENQ	DEG_APCC_KENBOX_2	305:309	Mutation altering degron motif	0.7701

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons