DegronMD

Uniprot ID: Q9UL63

Source protein: Muskelin

Source gene: MKLN1

Class: DEG_APCC_KENBOX_2

Location: 305:309

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5402

ASA_SCORE: 85.66

COIL: 0.8054

CONS_SCORE: 0.5074

DSS_SCORE: 0.144

HELIX: 0.0056

FCONS_SCORE: 0.9226

RIG_SCORE: 0.8732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A302V	TCGA-50-5944	LUAD	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.25
p.S314C	TCGA-55-8205	LUAD	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.1944
p.E318D	TCGA-78-7158	LUAD	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.0833
p.V305A	TCGA-A5-A1OF	UCEC	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.5825
p.D316E	TCGA-CA-6717	COAD	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.1389
p.M308T	DO7930	COAD	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.7423
p.G313D	DO14160	HNSC	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.2222
p.C319F	DO26015	LUAD	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.1667
p.C301Y	DO42023	UCEC	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.2222
p.S304L	C-4-I	cervix	COSMIC	VKENQ	DEG_APCC_KENBOX_2	0.3056
p.M300I	HCC1599	breast	COSMIC	VKENQ	DEG_APCC_KENBOX_2	0.1944
p.E305A	HCC2998	large_intestine	COSMIC	VKENQ	DEG_APCC_KENBOX_2	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15746	Myosin light chain kinase, smooth muscle	DEG_APCC_KENBOX_2	425:429	VKENQ	APC,CDC20,FZR1	0.8676	More...
Q9UL63	Muskelin	DEG_APCC_KENBOX_2	305:309	VKENQ	APC,CDC20,FZR1	0.5402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons