DegronMD

Uniprot ID: Q15746

Source protein: Myosin light chain kinase, smooth muscle

Source gene: MYLK

Class: DEG_APCC_KENBOX_2

Location: 425:429

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8676

ASA_SCORE: 86.14

COIL: 0.6786

CONS_SCORE: 0.337

DSS_SCORE: 0.4828

HELIX: 0.0024

FCONS_SCORE: 0.9168

RIG_SCORE: 0.7372

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E417K	TCGA-66-2773	LUSC	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.1111
p.E417K	DO26536	LUSC	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.1111
p.K426N	TCGA-AA-3864	COAD	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.6918
p.K426N	DO8490	COAD	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.6918
p.V425I	TCGA-AN-A0AK	BRCA	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.5965
p.V425I	TCGA-YD-A9TA	SKCM	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.5965
p.V425I	DO1608	BRCA	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.5965
p.V425I	DO219503	SKCM	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.5965
p.E417D	TCGA-CF-A1HS	BLCA	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.1111
p.E417D	DO486	BLCA	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.1111
p.G439W	TCGA-CV-7250	HNSC	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.0556
p.G439W	DO15070	HNSC	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.0556
p.E427K	TCGA-D3-A2JP	SKCM	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.7022
p.E427K	TCGA-EE-A2A2	SKCM	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.7022
p.E427K	TCGA-ER-A199	SKCM	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.7022
p.E427K	TCGA-FS-A4F0	SKCM	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.7022
p.E427K	DO37583	SKCM	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.7022
p.E427K	DO37891	SKCM	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.7022
p.E427K	DO47407	SKCM	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.7022
p.E427K	DO47395	SKCM	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.7022
p.V437G	TCGA-D8-A1XF	BRCA	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.1111
p.V437G	DO4263	BRCA	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.1111
p.G439R	TCGA-FW-A3TU	SKCM	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.0556
p.G439R	DO37441	SKCM	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.0556
p.G439R	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VKENQ	DEG_APCC_KENBOX_2	0.0556
p.G439R	ACH-001458	Colon/Colorectal Cancer	CCLE	VKENQ	DEG_APCC_KENBOX_2	0.0556
p.G439R	ACH-002222	Leukemia	CCLE	VKENQ	DEG_APCC_KENBOX_2	0.0556
p.G439R	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VKENQ	DEG_APCC_KENBOX_2	0.0556
p.E424D	TCGA-YD-A9TA	SKCM	TCGA	VKENQ	DEG_APCC_KENBOX_2	0.3056
p.E424D	DO219503	SKCM	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.3056
p.Q423K	DO228971	LICA	ICGC	VKENQ	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15746	Myosin light chain kinase, smooth muscle	DEG_APCC_KENBOX_2	425:429	VKENQ	APC,CDC20,FZR1	0.8676	More...
Q9UL63	Muskelin	DEG_APCC_KENBOX_2	305:309	VKENQ	APC,CDC20,FZR1	0.5402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKENQ

Degron related mutations and impact score

Drug responses associated with MYLK mutations

All proteins holding degron of VKENQ