DegronMD - Q9ULE6(PALD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G317C	TCGA-D3-A2J6	SKCM	TCGA	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.6489
p.G317C	DO37901	SKCM	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.6489
p.M323I	TCGA-D3-A2J6	SKCM	TCGA	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.6507
p.M323I	DO37901	SKCM	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.6507
p.V324F	TCGA-FJ-A3ZE	BLCA	TCGA	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.7068
p.V324F	DO484	BLCA	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.7068
p.R333C	TCGA-G5-6233	READ	TCGA	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1111
p.R333C	DO36626	READ	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1111
p.R333C	SIDM01546	Kidney Carcinoma	GDSC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1111
p.F310L	TCGA-XF-A8HD	BLCA	TCGA	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1389
p.F310L	DO49795	BLCA	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1389
p.V309F	DO229026	LICA	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1111
p.V309F	DO229008	LICA	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1111
p.H332Q	DO48694	LIRI	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.1389
p.G317D	DO229227	THCA	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.6087
p.G326C	SIDM00217	Colorectal Carcinoma	GDSC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.3056
p.G326C	ACH-000999	Colon/Colorectal Cancer	CCLE	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.3056
p.G326C	SNU-1040	large intestine	COSMIC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation rewiring degron network	0.3056
p.T319A	SIDM01612	Endometrial Carcinoma	GDSC	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.6028
p.T319A	ACH-000946	Endometrial/Uterine Cancer	CCLE	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.6028
p.L325M	ACH-001061	Colon/Colorectal Cancer	CCLE	GRTNLGMVL	DEG_APCC_DBOX_1	317:325	Mutation altering degron motif	0.5999

Kaplan plot for PALD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PALD1

UniProt ID: Q9ULE6

Entrez ID: 27143

Protein name: Paladin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PALD1 in