DegronMD

Uniprot ID: Q9ULE6

Source protein: Paladin

Source gene: PALD1

Class: DEG_APCC_DBOX_1

Location: 317:325

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6505

ASA_SCORE: 19.6778

COIL: 0.1401

CONS_SCORE: 0.6442

DSS_SCORE: 0.1571

HELIX: 0.8301

FCONS_SCORE: 1.2569

RIG_SCORE: 0.8027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G317C	TCGA-D3-A2J6	SKCM	TCGA	GRTNLGMVL	DEG_APCC_DBOX_1	0.6489
p.G317C	DO37901	SKCM	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	0.6489
p.M323I	TCGA-D3-A2J6	SKCM	TCGA	GRTNLGMVL	DEG_APCC_DBOX_1	0.6507
p.M323I	DO37901	SKCM	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	0.6507
p.V324F	TCGA-FJ-A3ZE	BLCA	TCGA	GRTNLGMVL	DEG_APCC_DBOX_1	0.7068
p.V324F	DO484	BLCA	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	0.7068
p.R333C	TCGA-G5-6233	READ	TCGA	GRTNLGMVL	DEG_APCC_DBOX_1	0.1111
p.R333C	DO36626	READ	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	0.1111
p.R333C	SIDM01546	Kidney Carcinoma	GDSC	GRTNLGMVL	DEG_APCC_DBOX_1	0.1111
p.F310L	TCGA-XF-A8HD	BLCA	TCGA	GRTNLGMVL	DEG_APCC_DBOX_1	0.1389
p.F310L	DO49795	BLCA	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	0.1389
p.V309F	DO229026	LICA	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	0.1111
p.V309F	DO229008	LICA	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	0.1111
p.H332Q	DO48694	LIRI	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	0.1389
p.G317D	DO229227	THCA	ICGC	GRTNLGMVL	DEG_APCC_DBOX_1	0.6087
p.G326C	SIDM00217	Colorectal Carcinoma	GDSC	GRTNLGMVL	DEG_APCC_DBOX_1	0.3056
p.G326C	ACH-000999	Colon/Colorectal Cancer	CCLE	GRTNLGMVL	DEG_APCC_DBOX_1	0.3056
p.G326C	SNU-1040	large_intestine	COSMIC	GRTNLGMVL	DEG_APCC_DBOX_1	0.3056
p.T319A	SIDM01612	Endometrial Carcinoma	GDSC	GRTNLGMVL	DEG_APCC_DBOX_1	0.6028
p.T319A	ACH-000946	Endometrial/Uterine Cancer	CCLE	GRTNLGMVL	DEG_APCC_DBOX_1	0.6028
p.L325M	ACH-001061	Colon/Colorectal Cancer	CCLE	GRTNLGMVL	DEG_APCC_DBOX_1	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULE6	Paladin	DEG_APCC_DBOX_1	317:325	GRTNLGMVL	APC,CDC20,FZR1	0.6505	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons