DegronMD - Q9ULG1(INO80)

INO80

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S122G	TCGA-66-2769	LUSC	TCGA	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5882
p.S122G	DO26522	LUSC	ICGC	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5882
p.K124N	TCGA-A5-A0G2	UCEC	TCGA	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5806
p.K124N	DO41235	UCEC	ICGC	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5806
p.D139Y	TCGA-HE-7130	KIRP	TCGA	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.0833
p.D139Y	DO20776	KIRP	ICGC	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.0833
p.S122R	DO229019	LICA	ICGC	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.6316
p.S128N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5958
p.S128N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation altering degron motif	0.5958
p.F116L	SIDM01611	Endometrial Carcinoma	GDSC	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.F116L	ACH-000996	Endometrial/Uterine Cancer	CCLE	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1667
p.E115D	YT	haematopoietic and lymphoid tissue	COSMIC	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.1389
p.A134S	KYSE-450	oesophagus	COSMIC	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.2222
p.A134D	SJRH30	soft tissue	COSMIC	SRKWLKSIL	DEG_APCC_DBOX_1	122:130	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc