DegronMD

Uniprot ID: Q9ULG1

Source protein: Chromatin-remodeling ATPase INO80

Source gene: INO80

Class: DEG_APCC_DBOX_1

Location: 122:130

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8947

ASA_SCORE: 67.6333

COIL: 0.2164

CONS_SCORE: 0.3358

DSS_SCORE: 0.2395

HELIX: 0.7693

FCONS_SCORE: 1.2669

RIG_SCORE: 0.7999

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S122G	TCGA-66-2769	LUSC	TCGA	SRKWLKSIL	DEG_APCC_DBOX_1	0.5882
p.S122G	DO26522	LUSC	ICGC	SRKWLKSIL	DEG_APCC_DBOX_1	0.5882
p.K124N	TCGA-A5-A0G2	UCEC	TCGA	SRKWLKSIL	DEG_APCC_DBOX_1	0.5806
p.K124N	DO41235	UCEC	ICGC	SRKWLKSIL	DEG_APCC_DBOX_1	0.5806
p.D139Y	TCGA-HE-7130	KIRP	TCGA	SRKWLKSIL	DEG_APCC_DBOX_1	0.0833
p.D139Y	DO20776	KIRP	ICGC	SRKWLKSIL	DEG_APCC_DBOX_1	0.0833
p.S122R	DO229019	LICA	ICGC	SRKWLKSIL	DEG_APCC_DBOX_1	0.6316
p.S128N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SRKWLKSIL	DEG_APCC_DBOX_1	0.5958
p.S128N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SRKWLKSIL	DEG_APCC_DBOX_1	0.5958
p.F116L	SIDM01611	Endometrial Carcinoma	GDSC	SRKWLKSIL	DEG_APCC_DBOX_1	0.1667
p.F116L	ACH-000996	Endometrial/Uterine Cancer	CCLE	SRKWLKSIL	DEG_APCC_DBOX_1	0.1667
p.E115D	YT	haematopoietic_and_lymphoid_tissue	COSMIC	SRKWLKSIL	DEG_APCC_DBOX_1	0.1389
p.A134S	KYSE-450	oesophagus	COSMIC	SRKWLKSIL	DEG_APCC_DBOX_1	0.2222
p.A134D	SJRH30	soft_tissue	COSMIC	SRKWLKSIL	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULG1	Chromatin-remodeling ATPase INO80	DEG_APCC_DBOX_1	122:130	SRKWLKSIL	APC,CDC20,FZR1	0.8947	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons