DegronMD - Q9ULH4(LRFN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R775W	TCGA-17-Z026	LUAD	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1389
p.R775Q	TCGA-28-5209	GBM	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1389
p.R775Q	TCGA-D7-8570	STAD	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1389
p.R775Q	DO11280	GBM	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1389
p.R775Q	DO48040	STAD	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1389
p.R775Q	SIDM00545	Melanoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1389
p.R775Q	ACH-000987	Skin Cancer	CCLE	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1389
p.T753M	TCGA-4Z-AA89	BLCA	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation blocking phosphorylation signal	0.5
p.T753M	DO218991	BLCA	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation blocking phosphorylation signal	0.5
p.G773W	TCGA-97-7553	LUAD	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1944
p.G773W	DO24020	LUAD	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1944
p.T753A	TCGA-AB-2807	LAML	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation blocking phosphorylation signal	0.5
p.T753A	DO21589	LAML	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation blocking phosphorylation signal	0.5
p.R755H	TCGA-DF-A2KU	UCEC	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.R755H	TCGA-FU-A3HZ	CESC	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.R755H	DO6308	CESC	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.R755H	DO222769	COCA	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.R755H	DO45299	LIRI	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.R755H	DO223286	UCEC	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.R755H	SIDM01943	Colorectal Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.G776E	TCGA-EE-A2GO	SKCM	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.G776E	TCGA-FR-A726	SKCM	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.G776E	DO37823	SKCM	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.G776E	DO48665	SKCM	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.R775L	TCGA-FS-A1ZC	SKCM	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1389
p.R775L	DO37487	SKCM	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1389
p.G761S	TCGA-OR-A5KB	ACC	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.S769I	TCGA-QH-A6XC	LGG	TCGA	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation blocking phosphorylation signal	0.75
p.S769I	DO50180	LGG	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation blocking phosphorylation signal	0.75
p.D770N	DO233885	GACA	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.D770N	DO228941	LICA	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.D770N	SIDM01265	Plasma Cell Myeloma	GDSC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.D770N	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.D770N	SIDM00489	Oral Cavity Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.D770N	SIDM01146	Gastric Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.D770N	SIDM00502	B-Lymphoblastic Leukemia	GDSC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.D770N	SIDM01609	Endometrial Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.G773R	DO23204	LINC	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1944
p.G773E	DO220896	MELA	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1944
p.G776R	DO220911	MELA	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.L763P	DO35242	PACA	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation altering degron motif	0.7582
p.L763F	DO232761	PBCA	ICGC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation altering degron motif	0.587
p.G761D	SIDM00438	B-Lymphoblastic Leukemia	GDSC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.G761D	ACH-002275	Leukemia	CCLE	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.G761D	MN-60	haematopoietic and lymphoid tissue	COSMIC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2778
p.R755C	SIDM00217	Colorectal Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.R755C	ACH-000999	Colon/Colorectal Cancer	CCLE	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.R755C	SNU-1040	large intestine	COSMIC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.1111
p.V759D	ACH-001591	Lung Cancer	CCLE	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2222
p.V759D	NCI-H1417	lung	COSMIC	LLPFEE	LIG_APCC_ABBA_1	763:768	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRFN2

UniProt ID: Q9ULH4

Entrez ID: 57497

Protein name: Leucine-rich repeat and fibronectin type-III domain-containing protein 2 (Synaptic adhesion-like molecule 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRFN2 in