DegronMD

Uniprot ID: Q9ULH4

Source protein: Leucine-rich repeat and fibronectin type-III domain-containing protein 2

Source gene: LRFN2

Class: LIG_APCC_ABBA_1

Location: 763:768

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5361

ASA_SCORE: 81.4333

COIL: 0.654

CONS_SCORE: 0.5697

DSS_SCORE: 0.2267

HELIX: 0.079

FCONS_SCORE: 1.1136

RIG_SCORE: 0.8405

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R775W	TCGA-17-Z026	LUAD	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.1389
p.R775Q	TCGA-28-5209	GBM	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.1389
p.R775Q	TCGA-D7-8570	STAD	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.1389
p.R775Q	DO11280	GBM	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1389
p.R775Q	DO48040	STAD	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1389
p.R775Q	SIDM00545	Melanoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	0.1389
p.R775Q	ACH-000987	Skin Cancer	CCLE	LLPFEE	LIG_APCC_ABBA_1	0.1389
p.T753M	TCGA-4Z-AA89	BLCA	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.5
p.T753M	DO218991	BLCA	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.5
p.G773W	TCGA-97-7553	LUAD	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.1944
p.G773W	DO24020	LUAD	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1944
p.T753A	TCGA-AB-2807	LAML	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.5
p.T753A	DO21589	LAML	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.5
p.R755H	TCGA-DF-A2KU	UCEC	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.R755H	TCGA-FU-A3HZ	CESC	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.R755H	DO6308	CESC	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.R755H	DO222769	COCA	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.R755H	DO45299	LIRI	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.R755H	DO223286	UCEC	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.R755H	SIDM01943	Colorectal Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.G776E	TCGA-EE-A2GO	SKCM	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.G776E	TCGA-FR-A726	SKCM	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.G776E	DO37823	SKCM	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.G776E	DO48665	SKCM	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.R775L	TCGA-FS-A1ZC	SKCM	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.1389
p.R775L	DO37487	SKCM	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1389
p.G761S	TCGA-OR-A5KB	ACC	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.S769I	TCGA-QH-A6XC	LGG	TCGA	LLPFEE	LIG_APCC_ABBA_1	0.75
p.S769I	DO50180	LGG	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.75
p.D770N	DO233885	GACA	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.D770N	DO228941	LICA	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.D770N	SIDM01265	Plasma Cell Myeloma	GDSC	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.D770N	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.D770N	SIDM00489	Oral Cavity Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.D770N	SIDM01146	Gastric Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.D770N	SIDM00502	B-Lymphoblastic Leukemia	GDSC	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.D770N	SIDM01609	Endometrial Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.G773R	DO23204	LINC	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1944
p.G773E	DO220896	MELA	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1944
p.G776R	DO220911	MELA	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.L763P	DO35242	PACA	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.7582
p.L763F	DO232761	PBCA	ICGC	LLPFEE	LIG_APCC_ABBA_1	0.587
p.G761D	SIDM00438	B-Lymphoblastic Leukemia	GDSC	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.G761D	ACH-002275	Leukemia	CCLE	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.G761D	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	LLPFEE	LIG_APCC_ABBA_1	0.2778
p.R755C	SIDM00217	Colorectal Carcinoma	GDSC	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.R755C	ACH-000999	Colon/Colorectal Cancer	CCLE	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.R755C	SNU-1040	large_intestine	COSMIC	LLPFEE	LIG_APCC_ABBA_1	0.1111
p.V759D	ACH-001591	Lung Cancer	CCLE	LLPFEE	LIG_APCC_ABBA_1	0.2222
p.V759D	NCI-H1417	lung	COSMIC	LLPFEE	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLPFEE

Degron related mutations and impact score

Drug responses associated with LRFN2 mutations

All proteins holding degron of LLPFEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULH4	Leucine-rich repeat and fibronectin type-III domain-containing protein 2	LIG_APCC_ABBA_1	763:768	LLPFEE	APC,CDC20,FZR1	0.5361	More...