DegronMD - Q9ULM0(PLEKHH1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P318T	TCGA-A1-A0SI	BRCA	TCGA	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.7031
p.P318T	DO1774	BRCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.7031
p.R322Q	DO228483	BRCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6218
p.R322Q	DO229003	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6218
p.R322Q	DO229505	LAML	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6218
p.R322Q	DO230990	LUSC	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6218
p.R322Q	DO52365	LUSC	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6218
p.N315T	DO229010	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.N315T	DO229013	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.N315T	DO229016	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.N315T	DO229003	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.N315T	DO229005	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.V315M	DO50753	LICA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.I308T	DO39074	THCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.0556
p.S309Y	DO43907	UCEC	ICGC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.0833
p.D323V	SIDM00434	Plasma Cell Myeloma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6674
p.D323V	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6674
p.D323V	SIDM01471	Chronic Myelogenous Leukemia	GDSC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6674
p.D323V	ACH-000482	Lung Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6674
p.D323V	ACH-000604	Leukemia	CCLE	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6674
p.D323V	ACH-000745	Myeloma	CCLE	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6674
p.D323V	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6674
p.D323V	RERF-LC-KJ	lung	COSMIC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.6674
p.P313L	SIDM00222	Mesothelioma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1944
p.P313L	SIDM01229	Neuroblastoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1944
p.P313L	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1944
p.P313L	SIDM01613	Colorectal Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1944
p.V315A	SIDM01045	Endometrial Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.V315A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.V315A	EN	endometrium	COSMIC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.P321L	SIDM01611	Endometrial Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.7582
p.P321L	ACH-000996	Endometrial/Uterine Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.7582
p.P318H	SIDM01573	Plasma Cell Myeloma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.7694
p.P318H	ACH-000576	Myeloma	CCLE	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.7694
p.R322W	ACH-001353	Pancreatic Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.7523
p.H332Q	ACH-001853	Bile Duct Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHH1

UniProt ID: Q9ULM0

Entrez ID: 57475

Protein name: Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHH1 in