DegronMD

Uniprot ID: Q9ULM0

Source protein: Pleckstrin homology domain-containing family H member 1

Source gene: PLEKHH1

Class: DEG_SCF_FBW7_1

Location: 318:324

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 80.5286

COIL: 0.8621

CONS_SCORE: 0.3656

DSS_SCORE: 0.6883

HELIX: 0.103

FCONS_SCORE: 1.0544

RIG_SCORE: 0.6463

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P318H	SIDM01573	Plasma Cell Myeloma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.7694
p.P318H	ACH-000576	Myeloma	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.7694
p.P321L	SIDM01611	Endometrial Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.7582
p.P321L	ACH-000996	Endometrial/Uterine Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.7582
p.R322W	ACH-001353	Pancreatic Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.7523
p.P318T	TCGA-A1-A0SI	BRCA	TCGA	PGTPRDS	DEG_SCF_FBW7_1	0.7031
p.P318T	DO1774	BRCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.7031
p.D323V	SIDM00434	Plasma Cell Myeloma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	SIDM01471	Chronic Myelogenous Leukemia	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	ACH-000482	Lung Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	ACH-000604	Leukemia	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	ACH-000745	Myeloma	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	RERF-LC-KJ	lung	COSMIC	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.R322Q	DO228483	BRCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.6218
p.R322Q	DO229003	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.6218
p.R322Q	DO229505	LAML	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.6218
p.R322Q	DO230990	LUSC	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.6218
p.R322Q	DO52365	LUSC	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.6218
p.N315T	DO229010	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.N315T	DO229013	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.N315T	DO229016	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.N315T	DO229003	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.N315T	DO229005	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25

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Drug responses associated with PLEKHH1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PGTPRDS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULM0	Pleckstrin homology domain-containing family H member 1	DEG_SCF_FBW7_1	318:324	PGTPRDS	FBXW7	0.9956	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTPRDS

Degron related mutations and impact score

Drug responses associated with PLEKHH1 mutations

All proteins holding degron of PGTPRDS