DegronMD

Uniprot ID: Q9ULM0

Source protein: Pleckstrin homology domain-containing family H member 1

Source gene: PLEKHH1

Class: DEG_SCF_FBW7_1

Location: 318:324

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 80.5286

COIL: 0.8621

CONS_SCORE: 0.3656

DSS_SCORE: 0.6883

HELIX: 0.103

FCONS_SCORE: 1.0544

RIG_SCORE: 0.6463

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P318T	TCGA-A1-A0SI	BRCA	TCGA	PGTPRDS	DEG_SCF_FBW7_1	0.7031
p.P318T	DO1774	BRCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.7031
p.R322Q	DO228483	BRCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.6218
p.R322Q	DO229003	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.6218
p.R322Q	DO229505	LAML	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.6218
p.R322Q	DO230990	LUSC	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.6218
p.R322Q	DO52365	LUSC	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.6218
p.N315T	DO229010	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.N315T	DO229013	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.N315T	DO229016	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.N315T	DO229003	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.N315T	DO229005	COCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.V315M	DO50753	LICA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.I308T	DO39074	THCA	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.0556
p.S309Y	DO43907	UCEC	ICGC	PGTPRDS	DEG_SCF_FBW7_1	0.0833
p.D323V	SIDM00434	Plasma Cell Myeloma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	SIDM01471	Chronic Myelogenous Leukemia	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	ACH-000482	Lung Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	ACH-000604	Leukemia	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	ACH-000745	Myeloma	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.D323V	RERF-LC-KJ	lung	COSMIC	PGTPRDS	DEG_SCF_FBW7_1	0.6674
p.P313L	SIDM00222	Mesothelioma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.1944
p.P313L	SIDM01229	Neuroblastoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.1944
p.P313L	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.1944
p.P313L	SIDM01613	Colorectal Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.1944
p.V315A	SIDM01045	Endometrial Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.V315A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.V315A	EN	endometrium	COSMIC	PGTPRDS	DEG_SCF_FBW7_1	0.25
p.P321L	SIDM01611	Endometrial Carcinoma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.7582
p.P321L	ACH-000996	Endometrial/Uterine Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.7582
p.P318H	SIDM01573	Plasma Cell Myeloma	GDSC	PGTPRDS	DEG_SCF_FBW7_1	0.7694
p.P318H	ACH-000576	Myeloma	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.7694
p.R322W	ACH-001353	Pancreatic Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.7523
p.H332Q	ACH-001853	Bile Duct Cancer	CCLE	PGTPRDS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTPRDS

Degron related mutations and impact score

Drug responses associated with PLEKHH1 mutations

All proteins holding degron of PGTPRDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULM0	Pleckstrin homology domain-containing family H member 1	DEG_SCF_FBW7_1	318:324	PGTPRDS	FBXW7	0.9956	More...