DegronMD - Q9ULW3(ABT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A178G	TCGA-50-6590	LUAD	TCGA	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1111
p.A178G	DO24692	LUAD	ICGC	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1111
p.R180H	TCGA-AA-3867	COAD	TCGA	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1667
p.R180H	DO9634	COAD	ICGC	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1667
p.D201N	TCGA-AP-A0LM	UCEC	TCGA	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1389
p.D201N	DO43306	UCEC	ICGC	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1389
p.G192R	TCGA-BR-4357	STAD	TCGA	LQSVERGQR	SCF_FBXL2	186:194	Mutation altering degron motif	0.7568
p.G192R	DO38241	STAD	ICGC	LQSVERGQR	SCF_FBXL2	186:194	Mutation altering degron motif	0.7568
p.R194H	TCGA-CG-5726	STAD	TCGA	LQSVERGQR	SCF_FBXL2	186:194	Mutation altering degron motif	0.8244
p.R194H	DO230342	COCA	ICGC	LQSVERGQR	SCF_FBXL2	186:194	Mutation altering degron motif	0.8244
p.R194H	DO38483	STAD	ICGC	LQSVERGQR	SCF_FBXL2	186:194	Mutation altering degron motif	0.8244
p.A178V	TCGA-EE-A2GC	SKCM	TCGA	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1111
p.A178V	DO37839	SKCM	ICGC	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1111
p.T182I	TCGA-FR-A726	SKCM	TCGA	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.2222
p.T182I	DO48665	SKCM	ICGC	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.2222
p.D199N	TCGA-L5-A8NS	ESCA	TCGA	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1944
p.Q193R	DO225292	BRCA	ICGC	LQSVERGQR	SCF_FBXL2	186:194	Mutation altering degron motif	0.6218
p.K179N	DO23442	LINC	ICGC	LQSVERGQR	SCF_FBXL2	186:194	Mutation blocking ubiquitination signal	0.5833
p.E181D	SIDM00142	Endometrial Carcinoma	GDSC	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1944
p.E181D	ACH-000864	Endometrial/Uterine Cancer	CCLE	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.1944
p.R204H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.0556
p.R204H	ACH-000918	Leukemia	CCLE	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.0556
p.R204H	ACH-002143	Skin Cancer	CCLE	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.0556
p.R204H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.0556
p.R204C	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LQSVERGQR	SCF_FBXL2	186:194	Mutation rewiring degron network	0.0556

Kaplan plot for ABT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABT1

UniProt ID: Q9ULW3

Entrez ID: 29777

Protein name: Activator of basal transcription 1 (hABT1) (Basal transcriptional activator)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABT1 in