DegronMD

Uniprot ID: Q9ULW3

Source protein: Activator of basal transcription 1

Source gene: ABT1

Class: SCF_FBXL2

Location: 186:194

E3 ligase: FBXL2

DEGRON score: 0.879

ASA_SCORE: 91.4556

COIL: 0.2366

CONS_SCORE: 0.4645

DSS_SCORE: 0.3779

HELIX: 0.7566

FCONS_SCORE: 1.2022

RIG_SCORE: 0.7864

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A178G	TCGA-50-6590	LUAD	TCGA	LQSVERGQR	SCF_FBXL2	0.1111
p.A178G	DO24692	LUAD	ICGC	LQSVERGQR	SCF_FBXL2	0.1111
p.R180H	TCGA-AA-3867	COAD	TCGA	LQSVERGQR	SCF_FBXL2	0.1667
p.R180H	DO9634	COAD	ICGC	LQSVERGQR	SCF_FBXL2	0.1667
p.D201N	TCGA-AP-A0LM	UCEC	TCGA	LQSVERGQR	SCF_FBXL2	0.1389
p.D201N	DO43306	UCEC	ICGC	LQSVERGQR	SCF_FBXL2	0.1389
p.G192R	TCGA-BR-4357	STAD	TCGA	LQSVERGQR	SCF_FBXL2	0.7568
p.G192R	DO38241	STAD	ICGC	LQSVERGQR	SCF_FBXL2	0.7568
p.R194H	TCGA-CG-5726	STAD	TCGA	LQSVERGQR	SCF_FBXL2	0.8244
p.R194H	DO230342	COCA	ICGC	LQSVERGQR	SCF_FBXL2	0.8244
p.R194H	DO38483	STAD	ICGC	LQSVERGQR	SCF_FBXL2	0.8244
p.A178V	TCGA-EE-A2GC	SKCM	TCGA	LQSVERGQR	SCF_FBXL2	0.1111
p.A178V	DO37839	SKCM	ICGC	LQSVERGQR	SCF_FBXL2	0.1111
p.T182I	TCGA-FR-A726	SKCM	TCGA	LQSVERGQR	SCF_FBXL2	0.2222
p.T182I	DO48665	SKCM	ICGC	LQSVERGQR	SCF_FBXL2	0.2222
p.D199N	TCGA-L5-A8NS	ESCA	TCGA	LQSVERGQR	SCF_FBXL2	0.1944
p.Q193R	DO225292	BRCA	ICGC	LQSVERGQR	SCF_FBXL2	0.6218
p.K179N	DO23442	LINC	ICGC	LQSVERGQR	SCF_FBXL2	0.5833
p.E181D	SIDM00142	Endometrial Carcinoma	GDSC	LQSVERGQR	SCF_FBXL2	0.1944
p.E181D	ACH-000864	Endometrial/Uterine Cancer	CCLE	LQSVERGQR	SCF_FBXL2	0.1944
p.R204H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LQSVERGQR	SCF_FBXL2	0.0556
p.R204H	ACH-000918	Leukemia	CCLE	LQSVERGQR	SCF_FBXL2	0.0556
p.R204H	ACH-002143	Skin Cancer	CCLE	LQSVERGQR	SCF_FBXL2	0.0556
p.R204H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	LQSVERGQR	SCF_FBXL2	0.0556
p.R204C	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LQSVERGQR	SCF_FBXL2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULW3	Activator of basal transcription 1	SCF_FBXL2	186:194	LQSVERGQR	FBXL2	0.879	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons