FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstre...
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland. {ECO:0000269|PubMed:20038531, ECO:0000269|PubMed:23105096}.
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GO - Biological processes (BP):
exocrine system development [GO:0035272]; Golgi to plasma membrane protein transport [GO:0043001]; regulated exocytosis [GO:0045055]; regulation of exocytosis [GO:0017157]; regulation of protein catabolic process at presynapse, modulating synaptic transmission [GO:0099575]...
exocrine system development [GO:0035272]; Golgi to plasma membrane protein transport [GO:0043001]; regulated exocytosis [GO:0045055]; regulation of exocytosis [GO:0017157]; regulation of protein catabolic process at presynapse, modulating synaptic transmission [GO:0099575]
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GO - Molecular function (MF):
GMP binding [GO:0019002]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]...
GMP binding [GO:0019002]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]
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GO - Cellular component (CC):
anchored component of synaptic vesicle membrane [GO:0098993]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intrinsic component of plasma membrane [GO:0031226]; secretory granule membrane [GO:0030667]...
anchored component of synaptic vesicle membrane [GO:0098993]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intrinsic component of plasma membrane [GO:0031226]; secretory granule membrane [GO:0030667]
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