DegronMD - Q9ULX6(AKAP8L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R98C	TCGA-2W-A8YY	CESC	TCGA	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.25
p.R98C	DO223732	CESC	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.25
p.R98C	SIDM00217	Colorectal Carcinoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.25
p.R98C	ACH-000999	Colon/Colorectal Cancer	CCLE	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.25
p.R98C	SNU-1040	large intestine	COSMIC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.25
p.P103S	TCGA-50-5066	LUAD	TCGA	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6752
p.P103S	DO25040	LUAD	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6752
p.N96I	TCGA-AO-A0J2	BRCA	TCGA	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.1944
p.N96I	DO2252	BRCA	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.1944
p.M101I	TCGA-CV-6948	HNSC	TCGA	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6507
p.M101I	DO14188	HNSC	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6507
p.R98H	TCGA-WS-AB45	COAD	TCGA	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.25
p.R98H	DO51734	COAD	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.25
p.R104H	DO10132	COAD	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.8244
p.D113N	DO8730	COAD	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.1389
p.V91I	DO222642	ESCA	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.0556
p.D113Y	DO233152	GACA	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.1389
p.M101V	DO233944	GACA	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6097
p.R104C	DO50810	LICA	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.8301
p.M94V	DO45139	LIRI	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.1389
p.R108H	DO50099	LUSC	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2778
p.M109T	DO35242	PACA	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.25
p.E93K	DO51407	PRAD	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.1111
p.A95T	DO41235	UCEC	ICGC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.1667
p.M110I	SIDM00845	Burkitt's Lymphoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2222
p.M110I	SIDM01519	Head and Neck Carcinoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2222
p.M110I	ACH-000992	Head and Neck Cancer	CCLE	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2222
p.M110I	Daudi	haematopoietic and lymphoid tissue	COSMIC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2222
p.V102M	SIDM00845	Burkitt's Lymphoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6097
p.V102M	SIDM01519	Head and Neck Carcinoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6097
p.V102M	ACH-000786	Lymphoma	CCLE	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6097
p.V102M	ACH-001067	Brain Cancer	CCLE	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6097
p.V102M	Daudi	haematopoietic and lymphoid tissue	COSMIC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6097
p.L99V	SIDM01450	Gastric Carcinoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2778
p.L99V	ACH-000898	Gastric Cancer	CCLE	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2778
p.R110H	SNU-175	large intestine	COSMIC	MVPHLE	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2222

Kaplan plot for AKAP8L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP8L

UniProt ID: Q9ULX6

Entrez ID: 26993

Protein name: A-kinase anchor protein 8-like (AKAP8-like protein) (Helicase A-binding protein 95) (HAP95) (Homologous to AKAP95 protein) (HA95) (Neighbor of A-kinase-anchoring protein 95) (Neighbor of AKAP95)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKAP8L in