DegronMD

Uniprot ID: Q9ULX6

Source protein: A-kinase anchor protein 8-like

Source gene: AKAP8L

Class: LIG_APCC_ABBA_1

Location: 101:106

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9991

ASA_SCORE: 81.15

COIL: 0.7663

CONS_SCORE: 0.7593

DSS_SCORE: 0.4828

HELIX: 0.1127

FCONS_SCORE: 1.1375

RIG_SCORE: 0.7913

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R98C	TCGA-2W-A8YY	CESC	TCGA	MVPHLE	LIG_APCC_ABBA_1	0.25
p.R98C	DO223732	CESC	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.25
p.R98C	SIDM00217	Colorectal Carcinoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	0.25
p.R98C	ACH-000999	Colon/Colorectal Cancer	CCLE	MVPHLE	LIG_APCC_ABBA_1	0.25
p.R98C	SNU-1040	large_intestine	COSMIC	MVPHLE	LIG_APCC_ABBA_1	0.25
p.P103S	TCGA-50-5066	LUAD	TCGA	MVPHLE	LIG_APCC_ABBA_1	0.6752
p.P103S	DO25040	LUAD	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.6752
p.N96I	TCGA-AO-A0J2	BRCA	TCGA	MVPHLE	LIG_APCC_ABBA_1	0.1944
p.N96I	DO2252	BRCA	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.1944
p.M101I	TCGA-CV-6948	HNSC	TCGA	MVPHLE	LIG_APCC_ABBA_1	0.6507
p.M101I	DO14188	HNSC	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.6507
p.R98H	TCGA-WS-AB45	COAD	TCGA	MVPHLE	LIG_APCC_ABBA_1	0.25
p.R98H	DO51734	COAD	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.25
p.R104H	DO10132	COAD	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.8244
p.D113N	DO8730	COAD	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.1389
p.V91I	DO222642	ESCA	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.0556
p.D113Y	DO233152	GACA	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.1389
p.M101V	DO233944	GACA	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.6097
p.R104C	DO50810	LICA	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.8301
p.M94V	DO45139	LIRI	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.1389
p.R108H	DO50099	LUSC	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.2778
p.M109T	DO35242	PACA	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.25
p.E93K	DO51407	PRAD	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.1111
p.A95T	DO41235	UCEC	ICGC	MVPHLE	LIG_APCC_ABBA_1	0.1667
p.M110I	SIDM00845	Burkitt's Lymphoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	0.2222
p.M110I	SIDM01519	Head and Neck Carcinoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	0.2222
p.M110I	ACH-000992	Head and Neck Cancer	CCLE	MVPHLE	LIG_APCC_ABBA_1	0.2222
p.M110I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MVPHLE	LIG_APCC_ABBA_1	0.2222
p.V102M	SIDM00845	Burkitt's Lymphoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	0.6097
p.V102M	SIDM01519	Head and Neck Carcinoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	0.6097
p.V102M	ACH-000786	Lymphoma	CCLE	MVPHLE	LIG_APCC_ABBA_1	0.6097
p.V102M	ACH-001067	Brain Cancer	CCLE	MVPHLE	LIG_APCC_ABBA_1	0.6097
p.V102M	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	MVPHLE	LIG_APCC_ABBA_1	0.6097
p.L99V	SIDM01450	Gastric Carcinoma	GDSC	MVPHLE	LIG_APCC_ABBA_1	0.2778
p.L99V	ACH-000898	Gastric Cancer	CCLE	MVPHLE	LIG_APCC_ABBA_1	0.2778
p.R110H	SNU-175	large_intestine	COSMIC	MVPHLE	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MVPHLE

Degron related mutations and impact score

Drug responses associated with AKAP8L mutations

All proteins holding degron of MVPHLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULX6	A-kinase anchor protein 8-like	LIG_APCC_ABBA_1	101:106	MVPHLE	APC,CDC20,FZR1	0.9991	More...