DegronMD - Q9UM22(EPDR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P2Q	TCGA-VQ-A94R	STAD	TCGA	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.3056
p.P2Q	DO222372	STAD	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.3056
p.T17A	DO223732	CESC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1667
p.V10I	DO230347	COCA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.5965
p.Q10H	DO222798	COCA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7582
p.K9R	DO50348	ESAD	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7237
p.K9R	DO234402	ESAD	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7237
p.R8S	DO234191	ESAD	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6316
p.R8S	SIDM01269	Esophageal Carcinoma	GDSC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6316
p.M14R	DO234367	ESAD	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.25
p.L7V	DO233750	GACA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6765
p.W5C	DO233888	GACA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7
p.G12D	DO233935	GACA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.3056
p.L16F	DO52087	HNSC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1944
p.L16F	DO20917	KIRP	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1944
p.A18S	DO228948	LICA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1389
p.K9N	DO229026	LICA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6918
p.R14L	DO229035	LICA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.25
p.D4Y	DO231155	LUSC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.7325
p.G18W	DO228221	MALY	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1389
p.D21N	DO51273	SKCM	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.0556
p.A5D	DO229245	THCA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation altering degron motif	0.6682
p.T17I	DO42673	UCEC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1667
p.K13N	DO42673	UCEC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.2778
p.H13Y	DO42665	UCEC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.2778
p.L16P	KM12	large intestine	COSMIC	GRAPLRTVP	DEG_APCC_DBOX_1	3:11	Mutation rewiring degron network	0.1944

Kaplan plot for EPDR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPDR1

UniProt ID: Q9UM22

Entrez ID: 54749

Protein name: Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPDR1 in