DegronMD

Uniprot ID: Q9UM22

Source protein: Mammalian ependymin-related protein 1

Source gene: EPDR1

Class: DEG_APCC_DBOX_1

Location: 3:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5759

ASA_SCORE: 82.6889

COIL: 0.8134

CONS_SCORE: 0.1626

DSS_SCORE: 0.3805

HELIX: 0.1072

FCONS_SCORE: 0.8088

RIG_SCORE: 0.7928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2Q	TCGA-VQ-A94R	STAD	TCGA	GRAPLRTVP	DEG_APCC_DBOX_1	0.3056
p.P2Q	DO222372	STAD	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.3056
p.T17A	DO223732	CESC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.1667
p.V10I	DO230347	COCA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.5965
p.Q10H	DO222798	COCA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.7582
p.K9R	DO50348	ESAD	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.7237
p.K9R	DO234402	ESAD	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.7237
p.R8S	DO234191	ESAD	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.6316
p.R8S	SIDM01269	Esophageal Carcinoma	GDSC	GRAPLRTVP	DEG_APCC_DBOX_1	0.6316
p.M14R	DO234367	ESAD	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.25
p.L7V	DO233750	GACA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.6765
p.W5C	DO233888	GACA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.7
p.G12D	DO233935	GACA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.3056
p.L16F	DO52087	HNSC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.1944
p.L16F	DO20917	KIRP	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.1944
p.A18S	DO228948	LICA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.1389
p.K9N	DO229026	LICA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.6918
p.R14L	DO229035	LICA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.25
p.D4Y	DO231155	LUSC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.7325
p.G18W	DO228221	MALY	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.1389
p.D21N	DO51273	SKCM	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.0556
p.A5D	DO229245	THCA	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.6682
p.T17I	DO42673	UCEC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.1667
p.K13N	DO42673	UCEC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.2778
p.H13Y	DO42665	UCEC	ICGC	GRAPLRTVP	DEG_APCC_DBOX_1	0.2778
p.L16P	KM12	large_intestine	COSMIC	GRAPLRTVP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UM22	Mammalian ependymin-related protein 1	DEG_APCC_DBOX_1	3:11	GRAPLRTVP	APC,CDC20,FZR1	0.5759	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons