DegronMD - Q9UM82(SPATA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R344W	TCGA-78-7145	LUAD	TCGA	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.2222
p.R325C	TCGA-AA-A01R	COAD	TCGA	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.0556
p.R325C	TCGA-MX-A5UJ	STAD	TCGA	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.0556
p.V335M	TCGA-EE-A29T	SKCM	TCGA	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation altering degron motif	0.6097
p.V335M	DO37742	SKCM	ICGC	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation altering degron motif	0.6097
p.V335M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation altering degron motif	0.6097
p.V335M	ACH-001127	Leukemia	CCLE	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation altering degron motif	0.6097
p.V335M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation altering degron motif	0.6097
p.T331A	TCGA-F5-6810	READ	TCGA	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.2222
p.T331A	DO37291	READ	ICGC	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.2222
p.R349W	TCGA-QB-A6FS	SKCM	TCGA	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.0833
p.R349W	DO48654	SKCM	ICGC	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.0833
p.C335R	DO5326	BRCA	ICGC	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation altering degron motif	0.8301
p.A331T	DO13522	GBM	ICGC	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.2222
p.R348H	DO51112	PRAD	ICGC	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.1111
p.R348H	SIDM00146	Breast Carcinoma	GDSC	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.1111
p.R348H	ACH-000768	Breast Cancer	CCLE	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.1111
p.R348H	MDA-MB-231	breast	COSMIC	VDLYTD	LIG_APCC_ABBA_1	335:340	Mutation rewiring degron network	0.1111

Kaplan plot for SPATA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA2

UniProt ID: Q9UM82

Entrez ID: 9825

Protein name: Spermatogenesis-associated protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA2 in