DegronMD

Uniprot ID: Q9UM82

Source protein: Spermatogenesis-associated protein 2

Source gene: SPATA2

Class: LIG_APCC_ABBA_1

Location: 335:340

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8912

ASA_SCORE: 67.2

COIL: 0.6218

CONS_SCORE: 0.5429

DSS_SCORE: 0.4952

HELIX: 0.2517

FCONS_SCORE: 1.216

RIG_SCORE: 0.798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R344W	TCGA-78-7145	LUAD	TCGA	VDLYTD	LIG_APCC_ABBA_1	0.2222
p.R325C	TCGA-AA-A01R	COAD	TCGA	VDLYTD	LIG_APCC_ABBA_1	0.0556
p.R325C	TCGA-MX-A5UJ	STAD	TCGA	VDLYTD	LIG_APCC_ABBA_1	0.0556
p.V335M	TCGA-EE-A29T	SKCM	TCGA	VDLYTD	LIG_APCC_ABBA_1	0.6097
p.V335M	DO37742	SKCM	ICGC	VDLYTD	LIG_APCC_ABBA_1	0.6097
p.V335M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VDLYTD	LIG_APCC_ABBA_1	0.6097
p.V335M	ACH-001127	Leukemia	CCLE	VDLYTD	LIG_APCC_ABBA_1	0.6097
p.V335M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VDLYTD	LIG_APCC_ABBA_1	0.6097
p.T331A	TCGA-F5-6810	READ	TCGA	VDLYTD	LIG_APCC_ABBA_1	0.2222
p.T331A	DO37291	READ	ICGC	VDLYTD	LIG_APCC_ABBA_1	0.2222
p.R349W	TCGA-QB-A6FS	SKCM	TCGA	VDLYTD	LIG_APCC_ABBA_1	0.0833
p.R349W	DO48654	SKCM	ICGC	VDLYTD	LIG_APCC_ABBA_1	0.0833
p.C335R	DO5326	BRCA	ICGC	VDLYTD	LIG_APCC_ABBA_1	0.8301
p.A331T	DO13522	GBM	ICGC	VDLYTD	LIG_APCC_ABBA_1	0.2222
p.R348H	DO51112	PRAD	ICGC	VDLYTD	LIG_APCC_ABBA_1	0.1111
p.R348H	SIDM00146	Breast Carcinoma	GDSC	VDLYTD	LIG_APCC_ABBA_1	0.1111
p.R348H	ACH-000768	Breast Cancer	CCLE	VDLYTD	LIG_APCC_ABBA_1	0.1111
p.R348H	MDA-MB-231	breast	COSMIC	VDLYTD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UM82	Spermatogenesis-associated protein 2	LIG_APCC_ABBA_1	335:340	VDLYTD	APC,CDC20,FZR1	0.8912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons