DegronMD - Q9UMQ6(CAPN11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R75K	TCGA-QC-A7B5	SARC	TCGA	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.3056
p.R75K	DO220239	SARC	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.3056
p.F66L	DO234464	ESAD	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.0556
p.G77W	DO50892	LICA	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation altering degron motif	0.6714
p.E81K	DO222868	MELA	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation altering degron motif	0.591
p.R70Q	DO229134	NKTL	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.1667
p.F85L	DO34072	PACA	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.25
p.S90N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.1111
p.S90N	ACH-002256	Leukemia	CCLE	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.1111
p.S90N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.1111
p.L69M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.1389
p.L69M	ACH-000922	Leukemia	CCLE	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.1389
p.L69M	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.1389
p.R75I	SIDM00118	Colorectal Carcinoma	GDSC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.3056
p.R75I	ACH-001081	Colon/Colorectal Cancer	CCLE	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.3056
p.R75I	HCC2998	large intestine	COSMIC	KGELFED	LIG_APCC_ABBAyCdc20_2	76:82	Mutation rewiring degron network	0.3056

Kaplan plot for CAPN11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAPN11

UniProt ID: Q9UMQ6

Entrez ID: 11131

Protein name: Calpain-11 (EC 3.4.22.-) (Calcium-activated neutral proteinase 11) (CANP 11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CAPN11 in