DegronMD

Uniprot ID: Q9UMQ6

Source protein: Calpain-11

Source gene: CAPN11

Class: LIG_APCC_ABBAyCdc20_2

Location: 76:82

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8755

ASA_SCORE: 63.6714

COIL: 0.788

CONS_SCORE: 0.6098

DSS_SCORE: 0.3067

HELIX: 0.079

FCONS_SCORE: 1.0981

RIG_SCORE: 0.7732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R75K	TCGA-QC-A7B5	SARC	TCGA	KGELFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.R75K	DO220239	SARC	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.F66L	DO234464	ESAD	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.0556
p.G77W	DO50892	LICA	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.6714
p.E81K	DO222868	MELA	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.591
p.R70Q	DO229134	NKTL	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.1667
p.F85L	DO34072	PACA	ICGC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.25
p.S90N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.S90N	ACH-002256	Leukemia	CCLE	KGELFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.S90N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.L69M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.L69M	ACH-000922	Leukemia	CCLE	KGELFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.L69M	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.1389
p.R75I	SIDM00118	Colorectal Carcinoma	GDSC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.R75I	ACH-001081	Colon/Colorectal Cancer	CCLE	KGELFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.R75I	HCC2998	large_intestine	COSMIC	KGELFED	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMQ6	Calpain-11	LIG_APCC_ABBAyCdc20_2	76:82	KGELFED	APC,CDC20,FZR1	0.8755	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons