DegronMD - Q9UMR7(CLEC4A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W178L	TCGA-05-4398	LUAD	TCGA	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.3056
p.W178L	DO25847	LUAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.3056
p.Y184C	TCGA-5N-A9KM	BLCA	TCGA	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation altering degron motif	0.5976
p.P170S	TCGA-97-A4M2	LUAD	TCGA	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.0833
p.R174Q	TCGA-AG-3892	READ	TCGA	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.1944
p.M194L	DO3152	BRCA	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.1111
p.R170H	DO234374	ESAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.0833
p.R170H	DO36279	PRAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.0833
p.R170H	DO49826	PRAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.0833
p.R170H	DO38380	STAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.0833
p.R169C	DO233944	GACA	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.0556
p.R169C	DO46657	PAAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.0556
p.V171F	DO229019	LICA	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.1111
p.V171F	DO27381	LUSC	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.1111
p.V172A	DO47867	STAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.1389
p.V171I	DO38336	STAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.1111
p.V181I	DO42673	UCEC	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation altering degron motif	0.7076
p.W176L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.25
p.W176L	ACH-000929	Lung Cancer	CCLE	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.25
p.W176L	NCI-H2110	lung	COSMIC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.25
p.R194L	ACH-000460	Ovarian Cancer	CCLE	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.1111
p.R181K	JVM-3	haematopoietic and lymphoid tissue	COSMIC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation altering degron motif	0.7237
p.Q193P	UWB1_289	ovary	COSMIC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.1389
p.R175K	JVM-3	haematopoietic and lymphoid tissue	COSMIC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.2222
p.Q187P	UWB1_289	ovary	COSMIC	VDQTPYNE	DEG_SCF_FBW7_2	179:186	Mutation rewiring degron network	0.3056

Kaplan plot for CLEC4A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLEC4A

UniProt ID: Q9UMR7

Entrez ID: 50856

Protein name: C-type lectin domain family 4 member A (C-type lectin DDB27) (C-type lectin superfamily member 6) (Dendritic cell immunoreceptor) (Lectin-like immunoreceptor) (CD antigen CD367)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLEC4A in