DegronMD

Uniprot ID: Q9UMR7

Source protein: C-type lectin domain family 4 member A

Source gene: CLEC4A

Class: DEG_SCF_FBW7_2

Location: 179:186

E3 ligase: FBXW7

DEGRON score: 0.7207

ASA_SCORE: 55.65

COIL: 0.8176

CONS_SCORE: 0.5939

DSS_SCORE: 0.4016

HELIX: 0.0195

FCONS_SCORE: 0.9542

RIG_SCORE: 0.7469

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W178L	TCGA-05-4398	LUAD	TCGA	VDQTPYNE	DEG_SCF_FBW7_2	0.3056
p.W178L	DO25847	LUAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.3056
p.Y184C	TCGA-5N-A9KM	BLCA	TCGA	VDQTPYNE	DEG_SCF_FBW7_2	0.5976
p.P170S	TCGA-97-A4M2	LUAD	TCGA	VDQTPYNE	DEG_SCF_FBW7_2	0.0833
p.R174Q	TCGA-AG-3892	READ	TCGA	VDQTPYNE	DEG_SCF_FBW7_2	0.1944
p.M194L	DO3152	BRCA	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.1111
p.R170H	DO234374	ESAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.0833
p.R170H	DO36279	PRAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.0833
p.R170H	DO49826	PRAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.0833
p.R170H	DO38380	STAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.0833
p.R169C	DO233944	GACA	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.0556
p.R169C	DO46657	PAAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.0556
p.V171F	DO229019	LICA	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.1111
p.V171F	DO27381	LUSC	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.1111
p.V172A	DO47867	STAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.1389
p.V171I	DO38336	STAD	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.1111
p.V181I	DO42673	UCEC	ICGC	VDQTPYNE	DEG_SCF_FBW7_2	0.7076
p.W176L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VDQTPYNE	DEG_SCF_FBW7_2	0.25
p.W176L	ACH-000929	Lung Cancer	CCLE	VDQTPYNE	DEG_SCF_FBW7_2	0.25
p.W176L	NCI-H2110	lung	COSMIC	VDQTPYNE	DEG_SCF_FBW7_2	0.25
p.R194L	ACH-000460	Ovarian Cancer	CCLE	VDQTPYNE	DEG_SCF_FBW7_2	0.1111
p.R181K	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	VDQTPYNE	DEG_SCF_FBW7_2	0.7237
p.Q193P	UWB1_289	ovary	COSMIC	VDQTPYNE	DEG_SCF_FBW7_2	0.1389
p.R175K	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	VDQTPYNE	DEG_SCF_FBW7_2	0.2222
p.Q187P	UWB1_289	ovary	COSMIC	VDQTPYNE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMR7	C-type lectin domain family 4 member A	DEG_SCF_FBW7_2	179:186	VDQTPYNE	FBXW7	0.7207	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons