DegronMD - Q9UN36(NDRG2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L34I	TCGA-EE-A2MM	SKCM	TCGA	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation rewiring degron network	0.0833
p.L34I	DO229035	LICA	ICGC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation rewiring degron network	0.0833
p.L34I	DO37770	SKCM	ICGC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation rewiring degron network	0.0833
p.S42C	TCGA-FD-A5BX	BLCA	TCGA	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation rewiring degron network	0.3056
p.T57I	DO228947	LICA	ICGC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation blocking phosphorylation signal	0.5556
p.T57I	SIDM00233	T-Lymphoblastic Leukemia	GDSC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation blocking phosphorylation signal	0.5556
p.T57I	SIDM01450	Gastric Carcinoma	GDSC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation blocking phosphorylation signal	0.5556
p.F38L	DO228976	LICA	ICGC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation rewiring degron network	0.1944
p.L52I	DO26430	LUSC	ICGC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation rewiring degron network	0.25
p.Y54H	DO232761	PBCA	ICGC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation rewiring degron network	0.1944
p.R48H	DO42280	UCEC	ICGC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation altering degron motif	0.8244
p.G56D	SIDM02050	Colorectal Carcinoma	GDSC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation rewiring degron network	0.1389
p.T45S	SIDM00656	Burkitt's Lymphoma	GDSC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation altering degron motif	0.7116
p.T45S	SIDM00785	Acute Myeloid Leukemia	GDSC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation altering degron motif	0.7116
p.T45S	SIDM00641	Burkitt's Lymphoma	GDSC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation altering degron motif	0.7116
p.M40T	SW1271	lung	COSMIC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation rewiring degron network	0.25
p.L45M	RKO	large intestine	COSMIC	VETPYGS	DEG_SCF_FBW7_1	43:49	Mutation altering degron motif	0.711

Kaplan plot for NDRG2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NDRG2

UniProt ID: Q9UN36

Entrez ID: 57447

Protein name: Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NDRG2 in