DegronMD

Uniprot ID: Q9UN36

Source protein: Protein NDRG2

Source gene: NDRG2

Class: DEG_SCF_FBW7_1

Location: 43:49

E3 ligase: FBXW7

DEGRON score: 0.9774

ASA_SCORE: 61.3714

COIL: 0.4024

CONS_SCORE: 0.6241

DSS_SCORE: 0.3608

HELIX: 0.0027

FCONS_SCORE: 1.4774

RIG_SCORE: 0.7197

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L34I	TCGA-EE-A2MM	SKCM	TCGA	VETPYGS	DEG_SCF_FBW7_1	0.0833
p.L34I	DO229035	LICA	ICGC	VETPYGS	DEG_SCF_FBW7_1	0.0833
p.L34I	DO37770	SKCM	ICGC	VETPYGS	DEG_SCF_FBW7_1	0.0833
p.S42C	TCGA-FD-A5BX	BLCA	TCGA	VETPYGS	DEG_SCF_FBW7_1	0.3056
p.T57I	DO228947	LICA	ICGC	VETPYGS	DEG_SCF_FBW7_1	0.5556
p.T57I	SIDM00233	T-Lymphoblastic Leukemia	GDSC	VETPYGS	DEG_SCF_FBW7_1	0.5556
p.T57I	SIDM01450	Gastric Carcinoma	GDSC	VETPYGS	DEG_SCF_FBW7_1	0.5556
p.F38L	DO228976	LICA	ICGC	VETPYGS	DEG_SCF_FBW7_1	0.1944
p.L52I	DO26430	LUSC	ICGC	VETPYGS	DEG_SCF_FBW7_1	0.25
p.Y54H	DO232761	PBCA	ICGC	VETPYGS	DEG_SCF_FBW7_1	0.1944
p.R48H	DO42280	UCEC	ICGC	VETPYGS	DEG_SCF_FBW7_1	0.8244
p.G56D	SIDM02050	Colorectal Carcinoma	GDSC	VETPYGS	DEG_SCF_FBW7_1	0.1389
p.T45S	SIDM00656	Burkitt's Lymphoma	GDSC	VETPYGS	DEG_SCF_FBW7_1	0.7116
p.T45S	SIDM00785	Acute Myeloid Leukemia	GDSC	VETPYGS	DEG_SCF_FBW7_1	0.7116
p.T45S	SIDM00641	Burkitt's Lymphoma	GDSC	VETPYGS	DEG_SCF_FBW7_1	0.7116
p.M40T	SW1271	lung	COSMIC	VETPYGS	DEG_SCF_FBW7_1	0.25
p.L45M	RKO	large_intestine	COSMIC	VETPYGS	DEG_SCF_FBW7_1	0.711

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UN36	Protein NDRG2	DEG_SCF_FBW7_1	43:49	VETPYGS	FBXW7	0.9774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons