DegronMD - Q9UN66(PCDHB8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V420I	TCGA-AA-A010	COAD	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1389
p.V420I	TCGA-AD-6895	COAD	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1389
p.V420I	TCGA-G4-6309	COAD	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1389
p.V420I	DO7810	COAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1389
p.V420I	DO8938	COAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1389
p.N437Y	TCGA-AO-A1KR	BRCA	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.2222
p.N437Y	DO4209	BRCA	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.2222
p.T421I	TCGA-AP-A051	UCEC	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1667
p.T421I	DO42673	UCEC	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1667
p.R431M	TCGA-AP-A059	UCEC	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.7521
p.R431M	DO41361	UCEC	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.7521
p.V440M	TCGA-AP-A1DV	UCEC	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1389
p.V440M	DO222804	COCA	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1389
p.V440M	DO234394	ESAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1389
p.V440M	DO43186	UCEC	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1389
p.R431S	TCGA-CV-5966	HNSC	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.6316
p.R431S	DO234205	ESAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.6316
p.R431S	DO14950	HNSC	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.6316
p.I422F	TCGA-EB-A44P	SKCM	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1944
p.I422F	DO47525	SKCM	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1944
p.L432P	TCGA-ER-A193	SKCM	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.6471
p.L432P	DO47368	SKCM	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.6471
p.M438V	TCGA-GN-A26C	SKCM	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1944
p.M438V	DO37782	SKCM	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1944
p.T439I	TCGA-IB-7651	PAAD	TCGA	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1667
p.T439I	DO46657	PAAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1667
p.L427V	DO234309	ESAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.5654
p.L427V	DO234292	ESAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.5654
p.G428E	DO222632	MELA	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.6087
p.G428E	DO229456	SKCA	ICGC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.6087
p.V424I	SIDM02049	Pancreatic Carcinoma	GDSC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.25
p.V424I	SIDM01301	Esophageal Carcinoma	GDSC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.25
p.V424I	SIDM01955	Colorectal Carcinoma	GDSC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.25
p.T429S	SIDM00683	Prostate Carcinoma	GDSC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.8227
p.T429S	LNCaP-Clone-FGC	prostate	COSMIC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation altering degron motif	0.8227
p.T439N	SIDM01001	Breast Carcinoma	GDSC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1667
p.T439N	DU-4475	breast	COSMIC	LGTPRLT	DEG_SCF_FBW7_1	427:433	Mutation rewiring degron network	0.1667

Kaplan plot for PCDHB8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHB8

UniProt ID: Q9UN66

Entrez ID: 56128

Protein name: Protocadherin beta-8 (PCDH-beta-8) (Protocadherin-3I)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHB8 in