DegronMD

Uniprot ID: Q9UN66

Source protein: Protocadherin beta-8

Source gene: PCDHB8

Class: DEG_SCF_FBW7_1

Location: 427:433

E3 ligase: FBXW7

DEGRON score: 0.8817

ASA_SCORE: 73.1143

COIL: 0.861

CONS_SCORE: 0.694

DSS_SCORE: 0.2378

HELIX: 0.008

FCONS_SCORE: 1.0556

RIG_SCORE: 0.7894

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V420I	TCGA-AA-A010	COAD	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.1389
p.V420I	TCGA-AD-6895	COAD	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.1389
p.V420I	TCGA-G4-6309	COAD	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.1389
p.V420I	DO7810	COAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.1389
p.V420I	DO8938	COAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.1389
p.N437Y	TCGA-AO-A1KR	BRCA	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.2222
p.N437Y	DO4209	BRCA	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.2222
p.T421I	TCGA-AP-A051	UCEC	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.1667
p.T421I	DO42673	UCEC	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.1667
p.R431M	TCGA-AP-A059	UCEC	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.7521
p.R431M	DO41361	UCEC	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.7521
p.V440M	TCGA-AP-A1DV	UCEC	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.1389
p.V440M	DO222804	COCA	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.1389
p.V440M	DO234394	ESAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.1389
p.V440M	DO43186	UCEC	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.1389
p.R431S	TCGA-CV-5966	HNSC	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.6316
p.R431S	DO234205	ESAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.6316
p.R431S	DO14950	HNSC	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.6316
p.I422F	TCGA-EB-A44P	SKCM	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.1944
p.I422F	DO47525	SKCM	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.1944
p.L432P	TCGA-ER-A193	SKCM	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.6471
p.L432P	DO47368	SKCM	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.6471
p.M438V	TCGA-GN-A26C	SKCM	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.1944
p.M438V	DO37782	SKCM	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.1944
p.T439I	TCGA-IB-7651	PAAD	TCGA	LGTPRLT	DEG_SCF_FBW7_1	0.1667
p.T439I	DO46657	PAAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.1667
p.L427V	DO234309	ESAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.5654
p.L427V	DO234292	ESAD	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.5654
p.G428E	DO222632	MELA	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.6087
p.G428E	DO229456	SKCA	ICGC	LGTPRLT	DEG_SCF_FBW7_1	0.6087
p.V424I	SIDM02049	Pancreatic Carcinoma	GDSC	LGTPRLT	DEG_SCF_FBW7_1	0.25
p.V424I	SIDM01301	Esophageal Carcinoma	GDSC	LGTPRLT	DEG_SCF_FBW7_1	0.25
p.V424I	SIDM01955	Colorectal Carcinoma	GDSC	LGTPRLT	DEG_SCF_FBW7_1	0.25
p.T429S	SIDM00683	Prostate Carcinoma	GDSC	LGTPRLT	DEG_SCF_FBW7_1	0.8227
p.T429S	LNCaP-Clone-FGC	prostate	COSMIC	LGTPRLT	DEG_SCF_FBW7_1	0.8227
p.T439N	SIDM01001	Breast Carcinoma	GDSC	LGTPRLT	DEG_SCF_FBW7_1	0.1667
p.T439N	DU-4475	breast	COSMIC	LGTPRLT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGTPRLT

Degron related mutations and impact score

Drug responses associated with PCDHB8 mutations

All proteins holding degron of LGTPRLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UN66	Protocadherin beta-8	DEG_SCF_FBW7_1	427:433	LGTPRLT	FBXW7	0.8817	More...