DegronMD - Q9UNA0(ADAMTS5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A93V	TCGA-17-Z037	LUAD	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2778
p.A93V	DO234230	ESAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2778
p.Y92F	TCGA-AC-A3W5	BRCA	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation blocking phosphorylation signal	0.6944
p.Y92F	DO49024	BRCA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation blocking phosphorylation signal	0.6944
p.K86N	TCGA-AF-2687	READ	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation substituting flanking lysine	0.1944
p.K86N	DO36902	READ	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation substituting flanking lysine	0.1944
p.V91I	TCGA-AG-3592	READ	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2222
p.V91I	DO234358	ESAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2222
p.V91I	DO233082	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2222
p.V91I	DO37308	READ	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2222
p.Y92C	TCGA-CD-8536	STAD	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation blocking phosphorylation signal	0.6944
p.Y92C	DO47827	STAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation blocking phosphorylation signal	0.6944
p.Y92C	ACH-000999	Colon/Colorectal Cancer	CCLE	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation blocking phosphorylation signal	0.6944
p.Y92C	SNU-1040	large intestine	COSMIC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation blocking phosphorylation signal	0.6944
p.G95S	TCGA-CK-6746	COAD	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation altering degron motif	0.5882
p.G95S	DO7938	COAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation altering degron motif	0.5882
p.D101Y	TCGA-DU-6392	LGG	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation altering degron motif	0.6214
p.D101Y	DO22237	LGG	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation altering degron motif	0.6214
p.S107P	TCGA-EO-A22U	UCEC	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2222
p.S107P	DO43755	UCEC	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2222
p.R96Q	TCGA-VS-A9UC	CESC	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation altering degron motif	0.7329
p.R96Q	DO219732	CESC	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation altering degron motif	0.7329
p.R96Q	DO233737	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation altering degron motif	0.7329
p.R96Q	DO35083	PACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation altering degron motif	0.7329
p.K86R	DO222877	COCA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation substituting flanking lysine	0.1944
p.R96W	DO234285	ESAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation altering degron motif	0.8634
p.G109D	DO233737	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.1667
p.A93T	DO233732	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2778
p.D105A	DO233869	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2778
p.G85D	DO231184	LAML	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.0556
p.S107W	DO52695	MALY	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.2222
p.L102M	DO52679	MALY	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation altering degron motif	0.5999
p.G112V	SIDM00719	Small Cell Lung Carcinoma	GDSC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.0833
p.G112V	ACH-001364	Lung Cancer	CCLE	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.0833
p.G112V	NCI-H345	lung	COSMIC	GRRFLLDLE	DEG_APCC_DBOX_1	95:103	Mutation rewiring degron network	0.0833

Kaplan plot for ADAMTS5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTS5

UniProt ID: Q9UNA0

Entrez ID: 11096

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTS5 in