DegronMD

Uniprot ID: Q9UNA0

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 5

Source gene: ADAMTS5

Class: DEG_APCC_DBOX_1

Location: 95:103

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5631

ASA_SCORE: 49.7556

COIL: 0.1156

CONS_SCORE: 0.9964

DSS_SCORE: 0.0828

HELIX: 0.0014

FCONS_SCORE: 1.1032

RIG_SCORE: 0.8979

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A93V	TCGA-17-Z037	LUAD	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.2778
p.A93V	DO234230	ESAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2778
p.Y92F	TCGA-AC-A3W5	BRCA	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.Y92F	DO49024	BRCA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.K86N	TCGA-AF-2687	READ	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.1944
p.K86N	DO36902	READ	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.1944
p.V91I	TCGA-AG-3592	READ	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.V91I	DO234358	ESAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.V91I	DO233082	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.V91I	DO37308	READ	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.Y92C	TCGA-CD-8536	STAD	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.Y92C	DO47827	STAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.Y92C	ACH-000999	Colon/Colorectal Cancer	CCLE	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.Y92C	SNU-1040	large_intestine	COSMIC	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.G95S	TCGA-CK-6746	COAD	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.5882
p.G95S	DO7938	COAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.5882
p.D101Y	TCGA-DU-6392	LGG	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.6214
p.D101Y	DO22237	LGG	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.6214
p.S107P	TCGA-EO-A22U	UCEC	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.S107P	DO43755	UCEC	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.R96Q	TCGA-VS-A9UC	CESC	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.7329
p.R96Q	DO219732	CESC	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.7329
p.R96Q	DO233737	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.7329
p.R96Q	DO35083	PACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.7329
p.K86R	DO222877	COCA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.1944
p.R96W	DO234285	ESAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.8634
p.G109D	DO233737	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.1667
p.A93T	DO233732	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2778
p.D105A	DO233869	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2778
p.G85D	DO231184	LAML	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.0556
p.S107W	DO52695	MALY	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.L102M	DO52679	MALY	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.5999
p.G112V	SIDM00719	Small Cell Lung Carcinoma	GDSC	GRRFLLDLE	DEG_APCC_DBOX_1	0.0833
p.G112V	ACH-001364	Lung Cancer	CCLE	GRRFLLDLE	DEG_APCC_DBOX_1	0.0833
p.G112V	NCI-H345	lung	COSMIC	GRRFLLDLE	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRRFLLDLE

Degron related mutations and impact score

Drug responses associated with ADAMTS5 mutations

All proteins holding degron of GRRFLLDLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UNA0	A disintegrin and metalloproteinase with thrombospondin motifs 5	DEG_APCC_DBOX_1	95:103	GRRFLLDLE	APC,CDC20,FZR1	0.5631	More...