DegronMD

Uniprot ID: Q9UNA0

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 5

Source gene: ADAMTS5

Class: DEG_APCC_DBOX_1

Location: 95:103

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5631

ASA_SCORE: 49.7556

COIL: 0.1156

CONS_SCORE: 0.9964

DSS_SCORE: 0.0828

HELIX: 0.0014

FCONS_SCORE: 1.1032

RIG_SCORE: 0.8979

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R96W	DO234285	ESAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.8634
p.R96Q	TCGA-VS-A9UC	CESC	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.7329
p.R96Q	DO219732	CESC	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.7329
p.R96Q	DO233737	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.7329
p.R96Q	DO35083	PACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.7329
p.Y92F	TCGA-AC-A3W5	BRCA	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.Y92F	DO49024	BRCA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.Y92C	TCGA-CD-8536	STAD	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.Y92C	DO47827	STAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.Y92C	ACH-000999	Colon/Colorectal Cancer	CCLE	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.Y92C	SNU-1040	large_intestine	COSMIC	GRRFLLDLE	DEG_APCC_DBOX_1	0.6944
p.D101Y	TCGA-DU-6392	LGG	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.6214
p.D101Y	DO22237	LGG	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.6214
p.L102M	DO52679	MALY	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.5999
p.G95S	TCGA-CK-6746	COAD	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.5882
p.G95S	DO7938	COAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.5882
p.A93V	TCGA-17-Z037	LUAD	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.2778
p.A93V	DO234230	ESAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2778
p.A93T	DO233732	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2778
p.D105A	DO233869	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2778
p.V91I	TCGA-AG-3592	READ	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.V91I	DO234358	ESAD	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.V91I	DO233082	GACA	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.V91I	DO37308	READ	ICGC	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222
p.S107P	TCGA-EO-A22U	UCEC	TCGA	GRRFLLDLE	DEG_APCC_DBOX_1	0.2222

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UNA0	A disintegrin and metalloproteinase with thrombospondin motifs 5	DEG_APCC_DBOX_1	95:103	GRRFLLDLE	APC,CDC20,FZR1	0.5631	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons