DegronMD - Q9UNA4(POLI)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D59Y	TCGA-95-A4VN	LUAD	TCGA	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.1111
p.D59Y	DO51199	LUAD	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.1111
p.V58E	TCGA-AG-A002	READ	TCGA	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.1389
p.A35S	TCGA-B2-5635	KIRC	TCGA	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.0833
p.A35S	DO17522	KIRC	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.0833
p.L60M	TCGA-EO-A22R	UCEC	TCGA	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.0833
p.L60M	DO42713	UCEC	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.0833
p.D42Y	TCGA-EO-A3AV	UCEC	TCGA	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.2778
p.D42Y	DO52412	UCEC	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.2778
p.V58M	DO222762	COCA	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.1389
p.A50S	DO229037	LICA	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation altering degron motif	0.6477
p.V44M	DO50970	LICA	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation altering degron motif	0.6097
p.D53Y	ACH-000766	Lung Cancer	CCLE	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.2778
p.D53Y	NCI-H1648	lung	COSMIC	VLPTPNAS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons