DegronMD

Uniprot ID: Q9UNA4

Source protein: DNA polymerase iota

Source gene: POLI

Class: DEG_SCF_FBW7_1

Location: 44:51

E3 ligase: FBXW7

DEGRON score: 0.7855

ASA_SCORE: 82.15

COIL: 0.8556

CONS_SCORE: 0.2619

DSS_SCORE: 0.3649

HELIX: 0.1109

FCONS_SCORE: 0.6438

RIG_SCORE: 0.7035

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D59Y	TCGA-95-A4VN	LUAD	TCGA	VLPTPNAS	DEG_SCF_FBW7_1	0.1111
p.D59Y	DO51199	LUAD	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	0.1111
p.V58E	TCGA-AG-A002	READ	TCGA	VLPTPNAS	DEG_SCF_FBW7_1	0.1389
p.A35S	TCGA-B2-5635	KIRC	TCGA	VLPTPNAS	DEG_SCF_FBW7_1	0.0833
p.A35S	DO17522	KIRC	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	0.0833
p.L60M	TCGA-EO-A22R	UCEC	TCGA	VLPTPNAS	DEG_SCF_FBW7_1	0.0833
p.L60M	DO42713	UCEC	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	0.0833
p.D42Y	TCGA-EO-A3AV	UCEC	TCGA	VLPTPNAS	DEG_SCF_FBW7_1	0.2778
p.D42Y	DO52412	UCEC	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	0.2778
p.V58M	DO222762	COCA	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	0.1389
p.A50S	DO229037	LICA	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	0.6477
p.V44M	DO50970	LICA	ICGC	VLPTPNAS	DEG_SCF_FBW7_1	0.6097
p.D53Y	ACH-000766	Lung Cancer	CCLE	VLPTPNAS	DEG_SCF_FBW7_1	0.2778
p.D53Y	NCI-H1648	lung	COSMIC	VLPTPNAS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UNA4	DNA polymerase iota	DEG_SCF_FBW7_1	44:51	VLPTPNAS	FBXW7	0.7855	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons