DegronMD - Q9UNN4(GTF2A1L)

GTF2A1L

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N417H	DO8264	COAD	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation rewiring degron network	0.25
p.P428S	DO227549	COCA	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation altering degron motif	0.6752
p.Q425K	DO234451	ESAD	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation altering degron motif	0.5833
p.C439F	DO228985	LICA	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation rewiring degron network	0.0833
p.T433M	DO26025	LUAD	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation rewiring degron network	0.25
p.P415L	DO26953	LUSC	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation rewiring degron network	0.1944
p.V411L	DO27723	LUSC	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation rewiring degron network	0.0833
p.S418F	DO26444	LUSC	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation rewiring degron network	0.2778
p.D434Y	DO32039	OV	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation rewiring degron network	0.2222
p.Q425H	DO232224	PBCA	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation altering degron motif	0.647
p.D434N	DO37404	SKCM	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation rewiring degron network	0.2222
p.S423T	DO41871	UCEC	ICGC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation altering degron motif	0.6005
p.A438V	Mewo	skin	COSMIC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation rewiring degron network	0.1111
p.V436L	H3255	lung	COSMIC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation rewiring degron network	0.1667
p.S423I	SLVL	haematopoietic and lymphoid tissue	COSMIC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation altering degron motif	0.623
p.G424C	Hs746T	stomach	COSMIC	DDVSEQDVPDL	DEG_COP1_1	420:430	Mutation altering degron motif	0.76

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*NOTE: the Kaplan plots were collected from OncoLnc