DegronMD

Uniprot ID: Q9UNN4

Source protein: TFIIA-alpha and beta-like factor

Source gene: GTF2A1L

Class: DEG_COP1_1

Location: 420:430

E3 ligase: COP1

DEGRON score: 0.9222

ASA_SCORE: 84.1909

COIL: 0.8375

CONS_SCORE: 0.535

DSS_SCORE: 0.5684

HELIX: 0.1205

FCONS_SCORE: 1.0187

RIG_SCORE: 0.7395

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N417H	DO8264	COAD	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.25
p.P428S	DO227549	COCA	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.6752
p.Q425K	DO234451	ESAD	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.5833
p.C439F	DO228985	LICA	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.0833
p.T433M	DO26025	LUAD	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.25
p.P415L	DO26953	LUSC	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.1944
p.V411L	DO27723	LUSC	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.0833
p.S418F	DO26444	LUSC	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.2778
p.D434Y	DO32039	OV	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.2222
p.Q425H	DO232224	PBCA	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.647
p.D434N	DO37404	SKCM	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.2222
p.S423T	DO41871	UCEC	ICGC	DDVSEQDVPDL	DEG_COP1_1	0.6005
p.A438V	Mewo	skin	COSMIC	DDVSEQDVPDL	DEG_COP1_1	0.1111
p.V436L	H3255	lung	COSMIC	DDVSEQDVPDL	DEG_COP1_1	0.1667
p.S423I	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	DDVSEQDVPDL	DEG_COP1_1	0.623
p.G424C	Hs746T	stomach	COSMIC	DDVSEQDVPDL	DEG_COP1_1	0.76

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UNN4	TFIIA-alpha and beta-like factor	DEG_COP1_1	420:430	DDVSEQDVPDL	COP1	0.9222	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons