DegronMD - Q9UNP9(PPIE)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K20T	TCGA-A5-A1OF	UCEC	TCGA	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation substituting flanking lysine	0.2778
p.K20T	DO42568	UCEC	ICGC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation substituting flanking lysine	0.2778
p.D18G	TCGA-AA-3713	COAD	TCGA	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1111
p.D18G	DO8400	COAD	ICGC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1111
p.D19N	TCGA-AX-A2HC	UCEC	TCGA	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.D19N	TCGA-BS-A0TC	UCEC	TCGA	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.D19N	DO41572	UCEC	ICGC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.D19N	DO42400	UCEC	ICGC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.Q36H	TCGA-AX-A2HC	UCEC	TCGA	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1944
p.Q36H	DO41572	UCEC	ICGC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1944
p.P38H	TCGA-EE-A2GN	SKCM	TCGA	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.P38H	DO37896	SKCM	ICGC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.P38S	TCGA-EE-A2MK	SKCM	TCGA	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.P38S	DO222615	MELA	ICGC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.P38S	DO38177	SKCM	ICGC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.D34N	TCGA-EO-A22U	UCEC	TCGA	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.25
p.D34N	DO43755	UCEC	ICGC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.25
p.A25V	TCGA-HU-A4GT	STAD	TCGA	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.3056
p.A25V	DO48020	STAD	ICGC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.3056
p.P38L	SIDM00545	Melanoma	GDSC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.P38L	ACH-000987	Skin Cancer	CCLE	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.P38L	Mewo	skin	COSMIC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation rewiring degron network	0.1389
p.P28L	SIDM00527	Colorectal Carcinoma	GDSC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.6471
p.P28L	ACH-000935	Colon/Colorectal Cancer	CCLE	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.6471
p.P28L	MDST8	large intestine	COSMIC	FIPFGD	LIG_APCC_ABBA_1	26:31	Mutation altering degron motif	0.6471

Kaplan plot for PPIE in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPIE

UniProt ID: Q9UNP9

Entrez ID: 10450

Protein name: Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PPIE in