DegronMD

Uniprot ID: Q9UNP9

Source protein: Peptidyl-prolyl cis-trans isomerase E

Source gene: PPIE

Class: LIG_APCC_ABBA_1

Location: 26:31

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6866

ASA_SCORE: 44.75

COIL: 0.6617

CONS_SCORE: 0.4618

DSS_SCORE: 0.065

HELIX: 0.1048

FCONS_SCORE: 1.2796

RIG_SCORE: 0.8767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K20T	TCGA-A5-A1OF	UCEC	TCGA	FIPFGD	LIG_APCC_ABBA_1	0.2778
p.K20T	DO42568	UCEC	ICGC	FIPFGD	LIG_APCC_ABBA_1	0.2778
p.D18G	TCGA-AA-3713	COAD	TCGA	FIPFGD	LIG_APCC_ABBA_1	0.1111
p.D18G	DO8400	COAD	ICGC	FIPFGD	LIG_APCC_ABBA_1	0.1111
p.D19N	TCGA-AX-A2HC	UCEC	TCGA	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.D19N	TCGA-BS-A0TC	UCEC	TCGA	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.D19N	DO41572	UCEC	ICGC	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.D19N	DO42400	UCEC	ICGC	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.Q36H	TCGA-AX-A2HC	UCEC	TCGA	FIPFGD	LIG_APCC_ABBA_1	0.1944
p.Q36H	DO41572	UCEC	ICGC	FIPFGD	LIG_APCC_ABBA_1	0.1944
p.P38H	TCGA-EE-A2GN	SKCM	TCGA	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.P38H	DO37896	SKCM	ICGC	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.P38S	TCGA-EE-A2MK	SKCM	TCGA	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.P38S	DO222615	MELA	ICGC	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.P38S	DO38177	SKCM	ICGC	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.D34N	TCGA-EO-A22U	UCEC	TCGA	FIPFGD	LIG_APCC_ABBA_1	0.25
p.D34N	DO43755	UCEC	ICGC	FIPFGD	LIG_APCC_ABBA_1	0.25
p.A25V	TCGA-HU-A4GT	STAD	TCGA	FIPFGD	LIG_APCC_ABBA_1	0.3056
p.A25V	DO48020	STAD	ICGC	FIPFGD	LIG_APCC_ABBA_1	0.3056
p.P38L	SIDM00545	Melanoma	GDSC	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.P38L	ACH-000987	Skin Cancer	CCLE	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.P38L	Mewo	skin	COSMIC	FIPFGD	LIG_APCC_ABBA_1	0.1389
p.P28L	SIDM00527	Colorectal Carcinoma	GDSC	FIPFGD	LIG_APCC_ABBA_1	0.6471
p.P28L	ACH-000935	Colon/Colorectal Cancer	CCLE	FIPFGD	LIG_APCC_ABBA_1	0.6471
p.P28L	MDST8	large_intestine	COSMIC	FIPFGD	LIG_APCC_ABBA_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UNP9	Peptidyl-prolyl cis-trans isomerase E	LIG_APCC_ABBA_1	26:31	FIPFGD	APC,CDC20,FZR1	0.6866	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons