DegronMD - Q9UNX9(KCNJ14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R369W	TCGA-AB-2828	LAML	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1389
p.R369W	DO233925	GACA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1389
p.R369W	DO21571	LAML	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1389
p.R347C	TCGA-BR-8382	STAD	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1111
p.R347C	DO47925	STAD	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1111
p.E371Q	TCGA-BT-A0YX	BLCA	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.0833
p.E371Q	DO516	BLCA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.0833
p.R351H	TCGA-DF-A2KU	UCEC	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.2222
p.R351H	DO223286	UCEC	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.2222
p.P356Q	TCGA-DK-A2I1	BLCA	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation altering degron motif	0.5924
p.P356Q	DO444	BLCA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation altering degron motif	0.5924
p.E365K	TCGA-EM-A2CO	THCA	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.25
p.E365K	DO38902	THCA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.25
p.K364N	TCGA-EO-A3KX	UCEC	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.2778
p.K364N	DO219774	UCEC	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.2778
p.E368V	TCGA-HD-8635	HNSC	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1667
p.E368V	DO14574	HNSC	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1667
p.D367N	TCGA-UF-A71D	HNSC	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1944
p.D367N	DO52109	HNSC	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1944
p.E354K	TCGA-UY-A78K	BLCA	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.3056
p.E354K	DO219031	BLCA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.3056
p.C361R	DO227979	COCA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation altering degron motif	0.719
p.R369Q	DO228696	EOPC	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.1389
p.R351C	SIDM00203	Ewing's Sarcoma	GDSC	VPGTPVCS	DEG_SCF_FBW7_1	355:362	Mutation rewiring degron network	0.2222

Kaplan plot for KCNJ14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNJ14

UniProt ID: Q9UNX9

Entrez ID: 3770

Protein name: ATP-sensitive inward rectifier potassium channel 14 (Inward rectifier K(+) channel Kir2.4) (IRK-4) (Potassium channel, inwardly rectifying subfamily J member 14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNJ14 in