DegronMD

Uniprot ID: Q9UNX9

Source protein: ATP-sensitive inward rectifier potassium channel 14

Source gene: KCNJ14

Class: DEG_SCF_FBW7_1

Location: 355:362

E3 ligase: FBXW7

DEGRON score: 0.9783

ASA_SCORE: 46.5375

COIL: 0.9535

CONS_SCORE: 0.4926

DSS_SCORE: 0.3736

HELIX: 0.0149

FCONS_SCORE: 1.0189

RIG_SCORE: 0.7391

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R369W	TCGA-AB-2828	LAML	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	0.1389
p.R369W	DO233925	GACA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.1389
p.R369W	DO21571	LAML	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.1389
p.R347C	TCGA-BR-8382	STAD	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	0.1111
p.R347C	DO47925	STAD	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.1111
p.E371Q	TCGA-BT-A0YX	BLCA	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	0.0833
p.E371Q	DO516	BLCA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.0833
p.R351H	TCGA-DF-A2KU	UCEC	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	0.2222
p.R351H	DO223286	UCEC	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.2222
p.P356Q	TCGA-DK-A2I1	BLCA	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	0.5924
p.P356Q	DO444	BLCA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.5924
p.E365K	TCGA-EM-A2CO	THCA	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	0.25
p.E365K	DO38902	THCA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.25
p.K364N	TCGA-EO-A3KX	UCEC	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	0.2778
p.K364N	DO219774	UCEC	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.2778
p.E368V	TCGA-HD-8635	HNSC	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	0.1667
p.E368V	DO14574	HNSC	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.1667
p.D367N	TCGA-UF-A71D	HNSC	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	0.1944
p.D367N	DO52109	HNSC	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.1944
p.E354K	TCGA-UY-A78K	BLCA	TCGA	VPGTPVCS	DEG_SCF_FBW7_1	0.3056
p.E354K	DO219031	BLCA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.3056
p.C361R	DO227979	COCA	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.719
p.R369Q	DO228696	EOPC	ICGC	VPGTPVCS	DEG_SCF_FBW7_1	0.1389
p.R351C	SIDM00203	Ewing's Sarcoma	GDSC	VPGTPVCS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UNX9	ATP-sensitive inward rectifier potassium channel 14	DEG_SCF_FBW7_1	355:362	VPGTPVCS	FBXW7	0.9783	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons