DegronMD - Q9UP52(TFR2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L271M	TCGA-55-8616	LUAD	TCGA	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.5999
p.L271M	DO23566	LUAD	ICGC	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.5999
p.T285A	TCGA-D1-A103	UCEC	TCGA	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.T285A	DO42312	UCEC	ICGC	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0833
p.R262S	DO228404	BRCA	ICGC	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1667
p.D258E	DO228974	LICA	ICGC	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.0556
p.V284L	DO50816	LIRI	ICGC	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1111
p.F280L	SIDM00499	Prostate Carcinoma	GDSC	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2222
p.F280L	SIDM00485	Oral Cavity Carcinoma	GDSC	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2222
p.V277A	SIDM01146	Gastric Carcinoma	GDSC	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.V277A	ACH-000932	Gastric Cancer	CCLE	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056
p.V277A	NCI-SNU-1	stomach	COSMIC	GRLLLVRVG	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons