DegronMD

Uniprot ID: Q9UP52

Source protein: Transferrin receptor protein 2

Source gene: TFR2

Class: DEG_APCC_DBOX_1

Location: 268:276

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6099

ASA_SCORE: 23.1556

COIL: 0.35

CONS_SCORE: 0.6007

DSS_SCORE: 0.0391

HELIX: 0.0147

FCONS_SCORE: 1.251

RIG_SCORE: 0.9094

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L271M	TCGA-55-8616	LUAD	TCGA	GRLLLVRVG	DEG_APCC_DBOX_1	0.5999
p.L271M	DO23566	LUAD	ICGC	GRLLLVRVG	DEG_APCC_DBOX_1	0.5999
p.T285A	TCGA-D1-A103	UCEC	TCGA	GRLLLVRVG	DEG_APCC_DBOX_1	0.0833
p.T285A	DO42312	UCEC	ICGC	GRLLLVRVG	DEG_APCC_DBOX_1	0.0833
p.R262S	DO228404	BRCA	ICGC	GRLLLVRVG	DEG_APCC_DBOX_1	0.1667
p.D258E	DO228974	LICA	ICGC	GRLLLVRVG	DEG_APCC_DBOX_1	0.0556
p.V284L	DO50816	LIRI	ICGC	GRLLLVRVG	DEG_APCC_DBOX_1	0.1111
p.F280L	SIDM00499	Prostate Carcinoma	GDSC	GRLLLVRVG	DEG_APCC_DBOX_1	0.2222
p.F280L	SIDM00485	Oral Cavity Carcinoma	GDSC	GRLLLVRVG	DEG_APCC_DBOX_1	0.2222
p.V277A	SIDM01146	Gastric Carcinoma	GDSC	GRLLLVRVG	DEG_APCC_DBOX_1	0.3056
p.V277A	ACH-000932	Gastric Cancer	CCLE	GRLLLVRVG	DEG_APCC_DBOX_1	0.3056
p.V277A	NCI-SNU-1	stomach	COSMIC	GRLLLVRVG	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UP52	Transferrin receptor protein 2	DEG_APCC_DBOX_1	268:276	GRLLLVRVG	APC,CDC20,FZR1	0.6099	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons