DegronMD - Q9UP65(PLA2G4C)

FUNCTION: Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:19501189, PubMed:9705332, PubMed:10085124, PubMed:10358058, PubMed:28336330). Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids (PubMed:19501189, PubMed:15944408). Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency (PubMed:19501189, PubMed:15944408). In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles (PubMed:28336330). {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:15944408, ECO:0000269|PubMed:19501189, ECO:0000269|PubMed:28336330, ECO:0000269|PubMed:9705332}.; FUNCTION: (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV) (PubMed:23015700, PubMed:28336330). In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur (PubMed:23015700). Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly (PubMed:23015700, PubMed:28336330). {ECO:0000269|PubMed:23015700, ECO:0000269|PubMed:28336330}.; FUNCTION: (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission. {ECO:0000269|PubMed:28639618}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G379V	TCGA-55-A490	LUAD	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation altering degron motif	0.7532
p.Y375C	TCGA-AA-A010	COAD	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.2778
p.Y375C	SIDM00217	Colorectal Carcinoma	GDSC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.2778
p.Y375C	ACH-000999	Colon/Colorectal Cancer	CCLE	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.2778
p.Y375C	SNU-1040	large intestine	COSMIC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.2778
p.R388L	TCGA-EE-A2MD	SKCM	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.25
p.G379D	TCGA-NH-A5IV	COAD	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation altering degron motif	0.7198
p.M385K	TCGA-NJ-A55A	LUAD	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation altering degron motif	0.8062
p.R388Q	TCGA-W5-AA31	CHOL	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.25
p.G369D	DO49095	COAD	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.1111
p.P393A	DO51037	LAML	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.1111
p.H367N	DO229034	LICA	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.0556
p.I390V	DO48589	LIHC	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.1944
p.G369V	DO24596	LUAD	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.1111
p.M375K	DO218945	LUAD	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.2778
p.A389V	DO222632	MELA	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.2222
p.R378L	DO37851	SKCM	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation altering degron motif	0.8428
p.I380N	SIDM02063	Colorectal Carcinoma	GDSC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation altering degron motif	0.728
p.S387I	SIDM00255	Neuroblastoma	GDSC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.2778
p.S387I	ACH-002282	Neuroblastoma	CCLE	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.2778
p.S387I	NB17	autonomic ganglia	COSMIC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation rewiring degron network	0.2778
p.S377I	NB17	autonomic ganglia	COSMIC	SRKHLHLVD	DEG_APCC_DBOX_1	377:385	Mutation altering degron motif	0.623

Kaplan plot for PLA2G4C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLA2G4C

UniProt ID: Q9UP65

Entrez ID: 8605

Protein name: Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLA2G4C in